Molecular Pathogenesis of Colorectal Cancer

1. The Genetics of Colorectal Cancer
William Hankey, Joanna Groden

2. Molecular Mechanisms of Colorectal Carcinogenesis
Jatin Roper, Kenneth E. Hung

3. The Association Between Inflammation and Colorectal Cancer
Maria José Oliveira, Sérgia Velho

4. Importance of the Niche: Wnt Signaling and Stem Cell Plasticity in Intestinal Homeostasis and Disease
Owen J. Sansom, Inke Näthke

5. Mutational Activation of KRAS and BRAF in Colorectal Cancer
Katherine H. Pedone, Jennifer L. Sells, Channing J. Der

6. The PI3K Pathway in Colorectal Cancers
Jihye Yun, George Poulogiannis, Evan T. Brower, Samuel Klempner, Lewis L. Cantley

7. TGF-ß Signaling Pathway and Colorectal Cancer
William M. Grady

8. The Clinical Significance of Mutations in Colorectal Cancer
Franklin W. Huang, Laura B. Kleiman, Theodore S. Hong

9. Colorectal Cancer Genome and Its Implications
Nickolas Papadopoulos

10. Copy-Number Alterations in the Colorectal Cancer Genome
Jihun Kim, Adam J. Bass

11. Genome-Wide Association Studies in Colorectal Cancer
Ian Tomlinson

12. Future Prospects for Leveraging Molecular Information in the Fight Against Colorectal Cancer
Laura B. Kleiman, Kevin M. Haigis

Nyckelord: Biomedicine, Cancer Research, Molecular Medicine, Protein Science, Cell Biology