Molecular Genetics of Inflammatory Bowel Disease

Part I. The Foundation of IBD Genetics, Human and Animal Studies

1. A Primer on IBD: Phenotypes, Diagnosis, Treatment, and Clinical Challenges
Xinjun Cindy Zhu, Richard P. MacDermott

2. Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies
Jonas Halfvarson

3. Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease
Emiko Mizoguchi, Atsushi Mizoguchi, Atul K. Bhan

Part II. The Genetic and Molecular Makeup of Inflammatory Bowel Disease

4. Complex Disease Genes and Their Discovery
Jeffrey C. Barrett, Mark J. Daly

5. The Genetics of Crohn’s Disease
Andre Franke, Miles Parkes

6. Genetics of Ulcerative Colitis
Mauro D’Amato, Catherine Labbé, John D. Rioux

7. Genetic Overlap Between Inflammatory Bowel Disease and Other Diseases
Charlie W. Lees, Alexandra Zhernakova

8. Molecular Profiling of IBD Subtypes/Response to Therapy
Isabelle Cleynen, Séverine Vermeire

9. Epigenetics of Inflammatory Bowel Disease
Robert Häsler, Stefan Schreiber, Stephan Beck, Philip Rosenstiel

Part III. Pathogenetic Pathways in Inflammatory Bowel Disease

10. Nod1 and Nod2 and the Immune Response to Bacteria
Maria Kaparakis-Liaskos, Dana J. Philpott

11. The IL23-Th17 Axis in Intestinal Inflammation
Kevin J. Maloy

12. Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics
Natalia B. Nedelsky, Petric Kuballa, Adam B. Castoreno, Ramnik J. Xavier

13. The Epithelial Barrier
Stefan Koch, Asma Nusrat, Charles A. Parkos

14. Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli”
Nouara Lhocine, Philippe J. Sansonetti

15. Cytokines in Inflammatory Bowel Disease
Matthias A. Engel, Markus F. Neurath

Part IV. Concluding Remarks and Future Perspectives

16. Towards Personalized Therapy in Inflammatory Bowel Disease
Dermot P. B. McGovern

Nyckelord: Biomedicine, Human Genetics, Molecular Medicine, Biomedicine general