Enzyme- and Transporter-Based Drug-Drug Interactions

1. Enzymatic Basis of Phase I and Phase II Drug Metabolism
Susan Kadlubar, Fred F. Kadlubar

2. Transporters: Importance in Drug Absorption, Distribution, and Removal
Frans G.M. Russel

3. ADME Pharmacogenetics and Its Impact on Drug–Drug Interactions
Reinhold Kerb, Matthias Schwab

4. Impact of Nuclear Receptors CAR, PXR, FXR, and VDR, and Their Ligands On Enzymes and Transporters
Rommel G. Tirona

5. Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances
K. Sandy Pang, Huadong Sun, Edwin C.Y. Chow

6. In Silico Approaches to Predict DDIs
Chad L. Stoner, Michael R. Wester, Benjamin J. Burke

7. In Vitro Techniques to Study Drug–Drug Interactions of Drug Metabolism: Cytochrome P450
J. Brian Houston, Aleksandra Galetin

8. The In Vitro Characterization of Inhibitory Drug–Drug Interactions Involving UDP-Glucuronosyltransferase
John O. Miners, Thomas M. Polasek, Peter I. Mackenzie, Kathleen M. Knights

9. In Vitro Techniques to Study Transporter-Based DDI
Kelly Bleasby, Xiaoyan Chu, Raymond Evers

10. In Vitro Techniques to Study Drug–Drug Interactions Involving Transport: Caco-2 Model for Study of P-Glycoprotein and Other Transporters
William R. Proctor, Xin Ming, Dhiren R. Thakker

11. Use of In Vivo Animal Models to Assess Drug–Drug Interactions
Thomayant Prueksaritanont

12. Extrapolation of In Vitro Metabolic and P-Glycoprotein-Mediated Transport Data to In Vivo by Modeling and Simulations
Motohiro Kato, Yoshihisa Shitara, Masato Kitajima, Tatsuhiko Tachibana, Masaki Ishigai, Toshiharu Horie, Yuichi Sugiyama

13. Translation of In Vitro Metabolic Data to Predict In Vivo Drug–Drug Interactions: IVIVE and Modeling and Simulations
Amin Rostami-Hodjegan

14. Absorption Models to Examine Bioavailability and Drug–Drug Interactions in Humans
Ahsan Naqi Rizwan, Kim L.R. Brouwer

15. Management of Drug Interactions of New Drugs in Multicenter Trials Using the Metabolism and Transport Drug Interaction Database©
Houda Hachad, Isabelle Ragueneau-Majlessi, René H. Levy

16. Web-Based Database as a Tool to Examine Drug–Drug Interactions Involving Transporters
Kazuya Maeda, Yoshihisa Shitara, Toshiharu Horie, Yuichi Sugiyama

17. Drug Disposition and Drug–Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver
Catherine K. Yeung, Ping Zhao, Danny D. Shen, Kenneth E. Thummel

18. Transporter-Based Drug–Drug Interactions and Their Effect on Distribution Volumes
Anita Grover, Leslie Z. Benet

19. Inactivation of Human Cytochrome P450 Enzymes and Drug–Drug Interactions
R. Scott Obach, Odette A. Fahmi, Robert L. Walsky

20. Allosteric Enzyme- and Transporter-Based Interactions
Murali Subramanian, Timothy S. Tracy

21. The Impact and In Vitro to In Vivo Prediction of Transporter-Based Drug–Drug Interactions in Humans
Jashvant D. Unadkat, Brian J. Kirby, Christopher J. Endres, Joseph K. Zolnerciks

22. Herbal Supplement-Based Interactions
Guohua An, Marilyn E. Morris

23. Anticipating and Minimizing Drug Interactions in a Drug Discovery and Development Setting: An Industrial Perspective
Ragini Vuppugalla, Sean Kim, Tatyana Zvyaga, Yong-hae Han, Praveen Balimane, Punit Marathe, A. David Rodrigues

24. Clinical Studies of Drug–Drug Interactions: Design and Interpretation
David J. Greenblatt, Lisa L. Moltke

25. Toxicological Consequences of Drug–Drug Interactions
Rachel J. Walsh, Abhishek Srivastava, Daniel J. Antoine, Dominic P. Williams, B. Kevin Park

26. Complex Drug Interactions: Significance and Evaluation
Ping Zhao, Lei Zhang, Shiew-Mei Huang

27. Drug–Drug Interactions: Communicating Post-market Drug Safety Information in the USA
Soraya Madani, Helen Winter

28. Drug–Drug Interactions: What Have We Learned and Where Are We Going?
K. Sandy Pang, Raimund M. Peter, A. David Rodrigues

Nyckelord: Biomedicine, Pharmacology/Toxicology, Analytical Chemistry, Medicinal Chemistry