Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Part I. Heat Shock Proteins and Neurodegenerative Diseases

1. Chaperones and Polyglutamine Expansion Disorders
Martin L. Duennwald

2. Heat Shock Proteins, Unfolded Protein Response Chaperones and Alzheimer’s Disease
Jordi Magrané, Henry W. Querfurth

3. Cellular and Molecular Mechanisms Underlying Parkinson’sDisease: The Role of Molecular Chaperones
Pamela J. Mclean

4. Heat Shock Proteins as Therapeutic Targets in Amyotrophic Lateral Sclerosis
Bernadett Kalmar, Linda Greensmith

5. The Role of Chaperones and Co-Chaperones in Retinal Degenerative Diseases
Maria Kosmaoglou, Tatiana V. Novoselova, Michael E. Cheetham

6. Neuroprotective Features Of Hsp90 Inhibitors Exhibiting Anti-Inflammatory Actions: Implications For Multiple Sclerosis
Douglas L. Feinstein, Alessandra Spagnolo, Cinzia Dello Russo

7. Role of HspB1 and HspB8 in Hereditary Peripheral Neuropathies: Beyond the Chaperone Function
Serena Carra, Jacques Landry

Part II. Heat Shock Proteins and Neuroprotection

8. Heat Shock Proteins Hsp70 and Hsp27 and Neural Cellular Protection
Tracy S. Voegeli, Amanda J. Wintink, R. William Currie

9. Molecular Chaperones and Protection in Animal and CellularModels of Ischemic Stroke
Yi-Bing Ouyang, Lijun Xu, Rona G. Giffard

10. Strategies for Conferring Neuroprotection and Countering the High Threshold for Induction of the Stress Response in Motor Neurons
Heather D. Durham

11. Use of Viral Gene Delivery Systems to Investigate the Neuroprotective Roles of Hsp70 and Hsp40 Proteins
Joanna Howarth, Do-Young Lee, James B. Uney

12. Heat Shock Proteins at the Synapse: Implications for Functional Protection of the Nervous System
Ian R. Brown

Part III. Extracellular Heat Shock Proteins and The Nervous System

13. Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System
Michael Tytell, Mac B. Robinson, Carolanne E. Milligan

14. Silencing of Metastasis-associated Gene 1 (Mta1) Stimulates Hsp70 Cellular Release and Neurite extension in Neuroblastoma Cells
N. K. Singh, Preethi Rao, Alexzander Asea

15. Extracellular Chaperones and Amyloids
Mark R. Wilson, Justin J. Yerbury, Stephen Poon

Part IV. Aging, Control Of Life Span and Expression Of Heat Shock Proteins

16. Neural Expression Of Small Heat Shock Proteins Influences Longevity And Resistance To Oxidative Stress
Robert M. Tanguay, Geneviève Morrow

17. Mechanistic Links Between Aging and Aggregation-Mediated Proteotoxicity: Role of HSF-1 and DAF-16
Ehud Cohen, Andrew Dillin

18. Protein Quality Control and Heat Shock Gene Expression in the Nervous System
Stuart K. Calderwood

19. Serum Hsp70 Level as a Biomarker of Exceptional Longevity
Dellara F. Terry, Alexzander Asea

20. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection
N. K. Singh, Preethi Rao, Alexzander Asea

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Nyckelord: TECHNOLOGY & ENGINEERING / Biomedical TEC059000