Statistics Applied to Clinical Trials

1. Hypotheses, Data, Stratification
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

2. The Analysis of Efficacy Data of Drug Trials
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

3. The Analysis of Safety Data of Drug Trials
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

4. Equivalence Testing
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

5. Statistical Power and Sample Size
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

6. Interim Analyses
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

7. Multiple Statistical Inferences
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

8. Controlling the Risk of False Positive Clinical Trials
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

9. The Interpretation of the P-Values
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

10. Research Data Closer to Expectation than Compatible with Random Sampling
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

11. Principles of Linear Regression
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

12. Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

13. Curvilinear Regression
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

14. Logistic and Cox Regression, Problems with Regression Modeling, Markow Models
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

15. Regression Modeling for Improved Precision
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

16. Post-Hoc Analyses in Clinical Trials, a Case for Logistic Regression Analysis
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

17. Interaction Effects in Clinical Trials
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

18. Meta-Analysis
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

19. Crossover Studies with Continuous Variables: Power Analysis
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

20. Crossover Studies with Binary Responses
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

21. Cross-Over Trials Should Not be Used to Test Treatments with Different Chemical Class
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

22. Quality-Of-Life Assessments in Clinical Trials
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

23. Statistical Analysis of Genetic Data
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

24. Relationship Among Statistical Distributions
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

25. Testing Clinical Trials for Randomness
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

26. Clinical Data where Variability is more Important than Averages
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

27. Testing Reproducibility
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

28. Accuracy of Diagnostic Tests
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

29. Advanced Analysis of Variance
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

30. Statistics is No “Bloodless” Algebra
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

31. Bias Due to Conflicts of Interests, some Guidelines
Ton J. Cleophas, Aeilko H. Zwinderman, Toine F. Cleophas

Nyckelord: Statistics, Statistics for Life Sciences, Medicine, Health Sciences, Statistics, general