Translational ADMET for Drug Therapy: Principles, Methods, and Pharmaceutical Applications

Absorption, distribution, metabolism, excretion, and toxicity (ADMET) are among the most critical factors that affect pharmacological response and drug safety. Preclinical and clinical tools and proof-of-concept investigations can improve drug design and make clinical investigations of drug candidate progress more effective. The correlation between in vitro, in vivo, and in silico ADMET data can further translate the pharmacokinetics and response of drugs across species and humans and bring forth new approaches towards better drug therapy by revealing hidden adverse side effects, adverse reactions, drug-drug interactions, and mechanisms of drug disposition.

To address this critical aspect of drug development, Translational ADMET for Drug Therapy presents effective technologies, methods, applications, data interpretation, and decision-making tactics for pharmaceutical and preclinical scientists. Chapters cover case studies and in vivo, in vitro, and in silico tools for optimal drug design, with new translational approaches to drug development and investigation.

Compiling the most effective approaches and technologies used to investigate ADMET and PKPD, this book offers a number of key benefits that include:

• Illustration of ADME properties from bedside to bench and bench to bedside, for the design of safe and effective medicine in human populations
• Examples that demonstrate the integration of in vitro, in vivo, and in silico data to address human PKPD and TKTD and help determine the proper therapeutic dosage
• Discussion of successful tools for evaluating drugs and covers current translational ADMET with regulatory guidelines
• A hands-on manual for researchers and scientists to design and execute in vitro, in silico, preclinical, and clinical studies

Nyckelord: Translational ADMET, in vitro, in silico, preclinical in vivo, pharmacokinetics, human populations, drug-drug interaction, toxicokinetics, predictive tools, drug discovery, clinical studies, Drug Discovery & Development