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Czechtizky, Werngard

Small Molecule Medicinal Chemistry: Strategies and Technologies

Czechtizky, Werngard - Small Molecule Medicinal Chemistry: Strategies and Technologies, e-bok

134,40€

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ISBN: 9781118771570
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Small molecules are the major source for marketed therapeutic drugs and valuable tools for studying biological pathways. To identify new small molecule therapeutics in an increasingly competitive environment, researchers need to keep up-to-date with the rapidly changing world of drug discovery.

This is where Small Molecule Medicinal Chemistry: Strategies and Technologies comes in, helping medicinal chemists and colleagues in related disciplines to identify and progress new innovative small molecules as efficiently as possible.

This book provides an overview of the field, with a focus on recent trends and up-to-date technologies for the identification and development of small molecule drugs. The all-inclusive set of successful techniques and methods is divided into 5 parts: access to new compound collections, new chemistries, lead identification strategies, technologies for medicinal chemistry optimization, and an overview of the chemical space beyond small molecules.

Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Among the key features, Small Molecule Medicinal Chemistry:

•    Discusses benefits, challenges, case studies, and industry perspectives for improving drug discovery programs in terms of quality and costs
•    Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages and challenges, as well as trends in the field from an industry perspective
•    Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches

Nyckelord: Medicinal chemistry, drug discovery, compound libraries, exploring biological space, virtual screening, phenotypic screening, drug design, ADME profiling, medicinal chemistry optimization, natural products drug discovery, peptidomimetics, Medicinal chemistry, drug discovery, compound libraries, exploring biological space, virtual screening, phenotypic screening, drug design, ADME profiling, medicinal chemistry optimization, natural products drug discovery, peptidomimetics, Medicinal chemistry, drug discovery, compound libraries, exploring biological space, virtual screening, phenotypic screening, drug design, ADME profiling, medicinal chemistry optimization, natural products drug discovery, peptidomimetics, Medicinal chemistry, drug discovery, compound libraries, exploring biological space, virtual screening, phenotypic screening, drug design, ADME profiling, medicinal chemistry optimization, natural products drug discovery, peptidomimetics, Pharmaceutical & Medicinal Chemistry

Utgivare
 
Utgivare
John Wiley and Sons, Inc.
Utgivningsår
2016
Språk
en
Utgåva
1
Sidantal
528 sidor
Kategori
Naturvetenskaper
Format
E-bok
eISBN (PDF)
9781118771570
Tryckt ISBN
9781118771600

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