Obesity and Overeating: Research Fundamentals

With the increasing worldwide incidence of obesity and the resulting increase in metabolic disorders such as diabetes, cardiovascular diseases and some cancers, an understanding of the multitude of factors that contribute to obesity is crucial for researchers to develop more effective treatments. This collection of overviews and protocols provides the reader with an introduction to the major features of obesity research, including the interplay between energy balance, hormones and neurobiological networks. An overview is provided which describes the animal models of obesity most commonly utilized in research. A standardized laboratory protocol for producing diet?]induced obesity (DIO) in both mouse and rat is provided as are protocols that describe how diet formulation can be modified to generate mouse models of human metabolic pathologies. Protocols are also provided for testing the effects of dietary manipulations, caloric restriction and potential therapeutics.

This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of obesity research for students or interdisciplinary collaborators.

Table of Contents:

Introduction

Energy Balance, Obesity and Type 2 Diabetes
eLS
M. Daniel Lane

Neurobiology of Overeating
eLS
Eric Stice and Kyle S. Burger

Primary Hormones and Receptors Studied in Obesity Research

Obesity Hormones in Health and Disease
eLS
Emrah Caylak

Central Dopaminergic Circuitry Controlling Food Intake and Reward: Implications for the Regulation of Obesity
WIREs Systems Biology and Medicine
Zivjena Vuceti and Teresa M. Reyes

Protocols

Overview of Animal Models of Obesity
Current Protocols in Pharmacology
Thomas A. Lutz and Stephen C. Woods

Diet-Induced Models of Obesity (DIO) in Rodents
Current Protocols in Neuroscience
Didier Bagnol, Hussien Al-Shamma, Dominic Behan, Kevin Whelan and Andrew J. Grottick

Dietary Manipulation of Mouse Metabolism
Current Protocols in Molecular Biology
Jerome N. Feige, Marie Lagouge and Johan Auwerx

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