Goodnow, Robert A.
A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
This book comprehensively describes the development and practice of DNA-encoded library synthesis technology. Together, the chapters detail an approach to drug discovery that offers an attractive addition to the portfolio of existing hit generation technologies such as high-throughput screening, structure-based drug discovery and fragment-based screening. The book:
- Provides a valuable guide for understanding and applying DNA-encoded combinatorial chemistry
- Helps chemists generate and screen novel chemical libraries of large size and quality
- Bridges interdisciplinary areas of DNA-encoded combinatorial chemistry – synthetic and analytical chemistry, molecular biology, informatics, and biochemistry
- Shows medicinal and pharmaceutical chemists how to efficiently broaden available “chemical space” for drug discovery
- Provides expert and up-to-date summary of reported literature for DNA-encoded and DNA-directed chemistry technology and methods
Nyckelord: DNA-encoded; combinatorial; drug discovery; chemical libraries; small molecules; tagging; chemistry; lead discovery; compound screening, Organic Chemistry, Biochemistry (Chemical Biology), Organic Chemistry, Biochemistry (Chemical Biology)
- Författare
- Goodnow, Robert A.
- Utgivare
- John Wiley and Sons, Inc.
- Utgivningsår
- 2014
- Språk
- en
- Utgåva
- 1
- Sidantal
- 480 sidor
- Kategori
- Naturvetenskaper
- Format
- E-bok
- eISBN (ePUB)
- 9781118832677
- Tryckt ISBN
- 9781118487686