Telomerases: Chemistry, Biology, and Clinical Applications

This book isa comprehensive and up-to-date review and evaluation of the contemporary status of telomerase research. Chapters in this volume cover the basic structure, mechanisms, and diversity of the essential and regulatory subunits of telomerase. Other topics include telomerase biogenesis, transcriptional and post-translational regulation, off-telomere functions of telomerase and the role of telomerase in cellular senescence, aging and cancer. Its relationship to retrotransposons, a class of mobile genetic elements that shares similarities with telomerase and serves as telomeres in selected organisms, are also reviewed.

Nyckelord: telomerase structure, telomerase research, telomerase biogenesis, off-telomere functions of telomerase, transcriptional regulation, post-translational regulation, regulatory subunits of telomerase, cellular senescence, aging, cancer, Cell & Molecular Biology, Medical Genetics, Cell & Molecular Biology, Medical Genetics