Cooper, Matthew
Label-Free Technologies For Drug Discovery
Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery.
Label-free technologies discussed include SPR, NMR, high-throughput mass spectrometry, resonant waveguide plate-based screening, transmitted-light imaging, isothermal titration calorimetry, optical and impedance cell-based assays and other biophysical methods. The technologies are discussed in relation to their use as screening technologies, high-content technologies, hit finding and hit validation strategies, mode of action and ADME/T, access to difficult target classes, cell-based receptor/ligand interactions particularly orphan receptors, and antibody and small molecule affinity and kinetic analysis.
Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.
Nyckelord: label-free technologies, drug discovery, drug development, analytical chemistry, label-free detecion systems, high-throughput screening, compound profiling teams, biomolecular interaction analysis, Cell & Molecular Biology, Analytical Chemistry, Cell & Molecular Biology, Analytical Chemistry
- Utgivare
- Cooper, Matthew
- Mayr, Lorenz M.
- Utgivare
- John Wiley and Sons, Inc.
- Utgivningsår
- 2010
- Språk
- en
- Utgåva
- 1
- Sidantal
- 328 sidor
- Kategori
- Hälsa, skönhet, mode
- Format
- E-bok
- eISBN (ePUB)
- 9781119990277
- Tryckt ISBN
- 9780470746837