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Supuran, Claudiu T.

Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications

Supuran, Claudiu T. - Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications, e-bok

174,25€

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ISBN: 9780470508152
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Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes

The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context.

With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as:

  • Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G

  • Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions

  • Cross reactivity of zinc-enzyme inhibitors and activators

  • The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins

  • Clinical applications

An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Författare
 
 
Utgivare
John Wiley and Sons, Inc.
Utgivningsår
2009
Språk
en
Utgåva
1
Serie
Wiley Series in Drug Discovery and Development
Sidantal
912 sidor
Kategori
Hälsa, skönhet, mode
Format
E-bok
eISBN (PDF)
9780470508152
Tryckt ISBN
9780470275009

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