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Boumendjel, Ahcène

ABC Transporters and Multidrug Resistance

Boumendjel, Ahcène - ABC Transporters and Multidrug Resistance, e-bok

150,50€

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ISBN: 9780470495124
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A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance

ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs.

ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance.

This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Nyckelord: scientific; resistance; abc; review; genes; cassette; comprehensive; research; transporter; current; mdr; ability; cells; pathologic; chemicals; develop; drug; eventually; medication; patients; several different; drugs; types, Pharmacology & Pharmaceutical Medicine, Cell & Molecular Biology, Pharmacology & Pharmaceutical Medicine, Cell & Molecular Biology

Utgivare
 
 
Utgivare
John Wiley and Sons, Inc.
Utgivningsår
2009
Språk
en
Utgåva
1
Serie
Wiley Series in Drug Discovery and Development
Sidantal
480 sidor
Kategori
Hälsa, skönhet, mode
Format
E-bok
eISBN (PDF)
9780470495124
Tryckt ISBN
9780470227343

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