Advances in Bioactivation Research

1. General Concepts and Basic Mechanisms

2. Metabolic Concerns in Drug Design
Jeffrey P. Jones

3. Role of Bioactivation in Idiosyncratic Drug Toxicity: Structure–Toxicity Relationships
Amit S. Kalgutkar

4. Michael Addition–Elimination Reactions: Roles in Toxicity and Potential New Therapeutic Applications
Adnan A. Elfarra, Renee J. Krause

5. Induction of Drug-Metabolizing Enzymes: Contrasting Roles in Detoxification and Bioactivation of Drugs and Xenobiotics
Sharon L. Ripp

6. Mechanism-Based Inactivation of Cytochrome P450 2A and 2B Enzymes
Sharon E. Murphy, Linda B. Weymarn

7. CYP2E1 – Biochemical and Toxicological Aspects and Role in Alcohol-Induced Liver Injury
Arthur I. Cederbaum

8. One- and Two-Electron-Mediated Reduction of Quinones: Enzymology and Toxicological Implications
David Siegel, Phillip Reigan, David Ross

9. Lipoxidation-Derived Electrophiles as Biological Reactive Intermediates
Lin, Lawrence M. Sayre

10. Bioactivation and Protein Modification Reactions of Unsaturated Aldehydes
J. Cai, B.G. Hill, A. Bhatnagar, W.M. Pierce, R.A. Prough

2. Tissue-Specific Features and Risk Assessment Applications

11. Adaptive Responses and Signal Transduction Pathways in Chemically Induced Mitochondrial Dysfunction and Cell Death
Lawrence H. Lash

12. Hepatic Bioactivation and Drug-Induced Liver Injury
Raymond A. Kemper, George Lai

13. Role of Cysteine S-Conjugate β-Lyases in the Bioactivation of Renal Toxicants
Arthur J. L. Cooper, John T. Pinto

14. Bioactivation of Xenobiotics in Lung: Role of CYPs and FMOs
David E. Williams

15. Generation of Reactive Metabolites and Associated DNA Adducts from Benzene, Butadiene, and PAH in Bone Marrow. Their Effects on Hematopoiesis and Impact on Human Health
Colin Jefcoate, Michele Larsen

16. Butadiene-Mediated Mutagenesis and Carcinogenesis
Jonathan B. Ward, Jeffrey K. Wickliffe, Michael P. Stone, Thomas M. Harris, Priscilla H. Fernandes, R. Stephen Lloyd

17. Pharmacogenetics of Drug Bioactivation Pathways
Lauren A. Trepanier

18. Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons
Stephen S. Hecht

Nyckelord: Biomedicine, Pharmacology/Toxicology, Immunology