Cell Stress Proteins

1. Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease
Stuart K. Calderwood

I. Stress Response and Molecular Chaperones

2. Biology of the Heat Shock Response and Stress Conditioning
George A. Perdrizet, Michael J. Rewinski, Emily J. Noonan, Lawrence E. Hightower

3. Bacterial Stress Sensors
Wolfgang Schumann

4. Unfolded Protein Response: Contributions to Development and Disease
Nan Liao, Linda M. Hendershot

II. Molecular Mechanisms of Stress Protein Expression

5. Genetic Models of HSF Function
András Orosz, Ivor J. Benjamin

6. HSF1 and HSP Gene Regulation
Richard Voellmy

III. Cellular Stress Proteins

7. Small Heat Shock Proteins in Physiological and Stress-Related Processes
Diana Orejuela, Anne Bergeron, Geneviève Morrow, Robert M. Tanguay

8. Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy
Xiang-Yang Wang, Douglas P. Easton, John R. Subjeck

IV. Molecular Chaperones and Protein Folding

9. Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors
Robert T. Youker, Jeffrey L. Brodsky

10. Protein Disassembly by Hsp40-Hsp70
Samuel J. Landry

11. Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol
Kazutoyo Terada, Masataka Mori

V. Role of Molecular Chaperones in Cell Regulation

12. FKBP Co-Chaperones in Steroid Receptor Complexes
Joyce Cheung-Flynn, Sean P. Place, Marc B. Cox, Viravan Prapapanich, David F. Smith

13. Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP
Shu-Bing Qian, Cam Patterson

14. Role of Cdc37 in Protein Kinase Folding
Atin K. Mandal, Devi M. Nair, Avrom J. Caplan

VI. Intracellular and Extracellular Stress Proteins in Human Disease

15. Targeting Hsp90 in Cancer and Neurodegenerative Disease
Len Neckers, Percy Ivy

16. gp96 and Tumor Immunity
Christopher V. Nicchitta

17. Immunoregulatory Activities of Extracellular Stress Proteins
A. Graham Pockley, Munitta Muthana

18. Heat Shock Proteins and Neurodegenerative Diseases
Ian R. Brown

19. Heat Shock Proteins in the Progression of Cancer
Stuart K. Calderwood, Abdul Khalique, Daniel R. Ciocca

Nyckelord: Life Sciences, Microbiology, Immunology, Biochemistry, general