Experimental Models of Multiple Sclerosis

Part A. Experimental Allergic (Autoimmune) Encephalomyelitis (EAE)

1. EAE: History, Clinical Signs, and Disease Course
J. William Lindsey

2. Induction of EAE
Eli Ben-Chetrit, Stefan Brocke

3. Histopathology of EAE
Michael J. Day

4. Neuroantigens in EAE
James Garbern

5. Adjuvants in EAE
Cris S Constantinescu, Brendan A Hilliard

6. The Role of Astrocytes in Autoimmune Disease of the Central Nervous System
Olaf Stüve, Scott S. Zamvil

7. Role of Microglia and Macrophages in Eae
Gennadij Raivich, Richard Banati

8. The Neuron and Axon in Experimental Autoimmune Encephalomyelitis
Nikos Evangelou, Cris S Constantinescu

9. Endothelial Cells and Adhesion Molecules in Experimental Autoimmune Encephalomyelitis
Jeri-Anne Lyons, Anne H. Cross

10. Genetics of Experimental Allergic Encephalomyelitis
David Baker

11. T Lymphocytes in EAE
Kelli Ryan, Stephen M Anderton

12. The Role of Complement in EAE
Johan Beek, B. Paul Morgan

13. B Cells and Antibodies in Experimental Autoimmune Encephalomyelitis
Xia Lin, Cris S Constantinescu

14. Cytokines in Experimental Autoimmune Encephalomyelitis
Cris S Constantinescu, David Baker

15. The Role of Interferons in Experimental Autoimmune Encephalomyelitis
Hubertine Heremans, Alfons Billiau

16. The Role of Growth Factors in Experimental Autoimmune Encephalomyelitis
Amy E. Lovett-Racke, Michael K. Racke

17. The Chemokine System in Experimental Autoimmune Encephalomyelitis
Andrzej R Glabinski, Richard M. Ransohoff

18. Free Radicals and Experimental Autoimmune Encephalomyelitis
Sean Murphy

19. Proteases and Peptidases in EAE
M Nicola Woodroofe, Rowena A D Bunning

20. The Blood-Brain Barrier in EAE
Britta Engelhardt, Hartwig Wolburg

21. Immunomodulation of EAE: Altered Peptide Ligands, Tolerance, and Th1/Th2
Brendan Hilliard, Youhai H. Chen

22. The Role of Costimulation in Experimental Autoimmune Encephalomyelitis
Michael K. Racke, Robert B. Ratts, Rodney W. Stuart, Caishu Deng, Amy E. Lovett-Racke

23. Epitope Spreading in EAE
Andrea E. Edling, Vincent K. Tuohy

24. Apoptotic Cell Death in Experimental Autoimmune Encephalomyelitis
Andrew Chan, Ralf Gold

25. Environmental Influences in Experimental Autoimmune Encephalomyelitis
Cris S Constantinescu

26. Hormonal and Gender Influences on Experimental Autoimmune Encephalomyelitis
Christopher Gilmore, Cris S Constantinescu, Caroline C Whitacre

27. Experimental Autoimmune Encephalomyelitis in Primates
Paul A. Smith, Sandra Amor, Bert A. ’tHart

Part B. Theiler’s Murine Encephalomyelitis Virus (TMEV) — Induced Demyelination

28. Histopathology in the Theiler’s Virus Model of Demyelination
D. R. Ure, M. Rodriguez

29. TMEV and Neuroantigens: Myelin Genes and Proteins, Molecular Mimicry, Epitope Spreading, and Autoantibody-Mediated Remyelination
Ikuo Tsunoda, Robert S. Fujinami

30. The Role of Astrocytes, Oligodendrocytes, Microglia and Endothelial Cells in TMEV Infection
M C Canto, C L VanderLugt

31. Immunogenetics, Resistance, and Susceptibility to Theiler’s Virus Infection
Roger W. Melvold, Stephen D. Miller

32. The Role of T Cells and the Innate Immune System in the Pathogenesis of Theiler’s Virus Demyeliating Disease
Julie K. Olson, Stephen D. Miller

33. Cytokines, Chemokines and Adhesion Molecules in TMEV-IDD
Byung S. Kim, Alyson C. Fuller, Chang-Sung Koh

34. Molecular Determinants of TMEV Pathogenesis
Stephen T. Guest, Raymond P. Roos

35. Nitric Oxide in TMEV
Emilia L. Oleszak, Jacek Kuzmak, Arun Varadhachary, Christos D. Katsetos

36. Theiler’s Murine Encephalomyelitis Virus (TMEV)-Induced Demyelination
Mary Lou Jelachich, Howard L. Lipton

Part C. Corona Virus-Induced Demyelination

37. Histopathology in Coronavirus-Induced Demyelination
Ehud Lavi

38. The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination
Yun Li, Ehud Lavi

39. Axons and Neurons in Corona Virus-Induced Demyelination
Ajai A. Dandekar, Stanley Perlman

40. The Role of T Cells in Corona-Virus-Induced Demyelination
Cornelia C Bergmann, Stephen A Stohlman, Stanley Perlman

41. The Role of Humoral Immunity in Mouse Hepatitis Virus Induced Demyelination
C. Ramakrishna, S. Tschen, C. C. Bergmann, S. A. Stohlman

42. The Role of T Cell Epitopes in Coronavirus Infection
Taeg S. Kim, Stanley Perlman

43. Coronaviruses and Neuroantigens: myelin proteins, myelin genes
Pierre J. Talbot, Annie Boucher, Pierre Duquette, Edith Gruslin

44. Coronavirus-Induced Demyelination and Spontaneous Remyelination
Regina C. Armstrong, Jeffrey M. Redwine, Donna J. Messersmith

45. Chemokines in Coronavirus-Induced Demyelination
Matthew J. Trifilo, Michael T. Liu, William G. Glass, Thomas E. Lane

46. Coronavirus Receptors
Fumihiro Taguchi

47. Apoptosis in MHV-Induced Demyelination
Talya Schwartz, Ehud Lavi

48. The Role of Metalloproteinases in Corona Virus Infection
Norman W. Marten, Jiehao Zhou

49. Molecular Determinants of Coronavirus Mhv- Induced Demyelination
Li Fu, Ehud Lavi

Part D. Demyelination Induced by Other Viruses

50. Semliki Forest Virus Induced Demyelination
John K. Fazakerley

51. The Pathogenesis of Canine Distemper Virus Induced Demyelination
Wolfgang Baumgärtner, Susanne Alldinger

Nyckelord: Biomedicine, Immunology, Virology, Neurosciences, Pathology, Neurology