Apoptotic Pathways as Targets for Novel Therapies in Cancer and Other Diseases

1. Apoptotic Pathways and Their Regulation
Greet Brouckaert, Michael Kalai, Xavier Saelens, Peter Vandenabeele

2. Mechanisms of Anticancer Drug Action
Sebastian Wesselborg, Kirsten Lauber

3. Death Receptor Pathways As Targets for Anticancer Therapy
Simone Fulda, Klaus-Michael Debatin

4. Caspases; Modulators of Apoptosis and Cytokine Maturation — Targets for Novel Therapies
Melissa J. Knight, Christine J. Hawkins

5. The Intrinsic (Mitochondrial) Death Pathway and New Cancer Therapeutics: Bcl-2 Family in Focus
Sanjeev Shangary, Christopher L. Oliver, Daniel E. Johnson

6. Survivin, other IAPs, Smac/Diablo, and Omi/Htra2 — Modulation of the Advancing Apoptotic Process
Fengzhi Li

7. The Life Cycle of P53: A Key Target in Drug Development
Lee E. Finlan, Ted R. Hupp

8. Growth Factors, Receptors, and Kinases: Their Exploration to Target Cancer
Jennifer G. Brown, Spencer B. Gibson

9. Targets for Apoptotic Intervention in Rheumatoid Arthritis
Steven C. Ghivizzani, Elvire Gouze, Jean-Noel Gouze

10. Therapeutic Inhibition of Apoptosis Caused by Stroke
Seth Love

11. Monoclonal and Bispecific Antibodies as Novel Therapeutics
Gundram Jung, Tanja Herrmann, Ludger Große-Hovest, Helmut Salih, Hans-Georg Rammensee

12. Targeting the Proteasome in Cancer Therapy
Robert Z. Orlowski

13. D-RNAi-Based Therapeutics
Shi-Lung Lin, Shao-Yao Ying

14. Nuclear Transcription Factor-?B: A Drug Target for all Seasons
Amit K. Garg, Bharat B. Aggarwal

15. Monitoring of Programmed cell Death in Vivo and in Vitro,—New and Old Methods of Cancer Therapy Assessment
Saeid Ghavami, Katarzyna Barczyk, Subbareddy Maddika, Thomas Vogl, Lars Steinmüller, Hamid Pour-Jafari, Jane A. Evans, Marek Los

16. Current Strategies in Tumor-Targeting
Walter Mier, Johannes Hoffend, Uwe Haberkorn, Michael Eisenhut

17. Strategies of Protection of Normal Cells During Chemo- and Radio-Therapy Based on Modulation of Cell Cycle and Apoptotic Pathways
Mikhail V. Blagosklonny, Zbigniew Darzynkiewicz

Nyckelord: Biomedicine, Pharmacology/Toxicology, Cancer Research, Cell Biology, Immunology, Human Genetics