RUNX Proteins in Development and Cancer

Part I. Evolution of RUNX Genes

1. RUNX in Invertebrates
S. Hughes, A. Woollard

Part II. RUNX and CBFβ: Structure and Function

2. Structure and Biophysics of CBFβ/RUNX and Its Translocation Products
Tahir H. Tahirov, John Bushweller

3. Covalent Modifications of RUNX Proteins: Structure Affects Function
Ezra Blumenthal, Sarah Greenblatt, Guang Huang, Koji Ando, Ye Xu, Stephen D. Nimer

Part III. RUNX Genes and Mammalian Development

4. The Role of Runx1 in Embryonic Blood Cell Formation
Amanda D. Yzaguirre, Marella F. T. R. Bruijn, Nancy A. Speck

5. Runx1 Structure and Function in Blood Cell Development
Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud

6. Roles of Runx2 in Skeletal Development
Toshihisa Komori

7. Mitotic Gene Bookmarking: An Epigenetic Mechanism for Coordination of Lineage Commitment, Cell Identity and Cell Growth
Sayyed K. Zaidi, Jane B. Lian, Andre Wijnen, Janet L. Stein, Gary S. Stein

8. Roles of Runx Genes in Nervous System Development
Jae Woong Wang, Stefano Stifani

9. Runx Family Genes in Tissue Stem Cell Dynamics
Chelsia Qiuxia Wang, Michelle Meng Huang Mok, Tomomasa Yokomizo, Vinay Tergaonkar, Motomi Osato

10. Roles of the RUNX1 Enhancer in Normal Hematopoiesis and Leukemogenesis
Wei-Siang Liau, Phuong Cao Thi Ngoc, Takaomi Sanda

Part IV. RUNX1 and CBFβ Fusion Proteins in Leukemia

11. RUNX1-ETO Leukemia
Shan Lin, James C. Mulloy, Susumu Goyama

12. Clinical Relevance of RUNX1 and CBFB Alterations in Acute Myeloid Leukemia and Other Hematological Disorders
Klaus H. Metzeler, Clara D. Bloomfield

13. Mechanism of ETV6-RUNX1 Leukemia
Aishwarya Sundaresh, Owen Williams

14.
ETV6-RUNX1

+
Acute Lymphoblastic Leukaemia in Identical Twins
Anthony M. Ford, Mel Greaves

15. Molecular Basis and Targeted Inhibition of CBFβ-SMMHC Acute Myeloid Leukemia
Lucio H. Castilla, John H. Bushweller

Part V. RUNX and CBFβ in Cancer and Immune Function

16. The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models
James C. Neil, Kathryn Gilroy, Gillian Borland, Jodie Hay, Anne Terry, Anna Kilbey

17. RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML
R. Katherine Hyde, Paul Liu, Alan D. Friedman

18. Roles of RUNX in B Cell Immortalisation
Michelle J. West, Paul J. Farrell

19. Roles of RUNX in Solid Tumors
Linda Shyue Huey Chuang, Kosei Ito, Yoshiaki Ito

20. RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras?
Jung-Won Lee, Andre Wijnen, Suk-Chul Bae

21.
Runx3 and Cell Fate Decisions in Pancreas Cancer
Martin C. Whittle, Sunil R. Hingorani

22.
Runx Genes in Breast Cancer and the Mammary Lineage
Nicholas Rooney, Alessandra I. Riggio, Daniel Mendoza-Villanueva, Paul Shore, Ewan R. Cameron, Karen Blyth

23. Runx3 in Immunity, Inflammation and Cancer
Joseph Lotem, Ditsa Levanon, Varda Negreanu, Omri Bauer, Shay Hantisteanu, Joseph Dicken, Yoram Groner

24. Roles of RUNX Complexes in Immune Cell Development
Takashi Ebihara, Wooseok Seo, Ichiro Taniuchi

25. CBFß and HIV Infection
Dong Young Kim, John D. Gross

Part VI. Emerging Roles for RUNX

26. Roles of RUNX in Hippo Pathway Signaling
Antonino Passaniti, Jessica L. Brusgard, Yiting Qiao, Marius Sudol, Megan Finch-Edmondson

27. Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis
Sun Hee Lee, Sarala Manandhar, You Mie Lee

28. The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition
Dominic Chih-Cheng Voon, Jean Paul Thiery

29. A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity
Vaidehi Krishnan, Yoshiaki Ito

Avainsanat: Biomedicine, Gene Function, Oncology, Protein Science