CCN proteins in health and disease

1. A Recent Breakthrough in the CCN Field: Functional Interactions Between CCN2 and CCN3 are Uncovered
Bernard Perbal

2. Report on the Fifth International Workshop on the CCN Family of Genes
A. E. Irvine, B. Perbal, H. Yeger

3. Asking the Right Questions: What Can the Structure of the CCN Protein Domains Tell Us?
Kenneth P. Holbourn, Bernard Perbal, K. Ravi Acharya

4. Nucleophosmin/B23: A Multifunctional Regulator that Determines the Fate of CCN2 mRNA
Satoshi Kubota, Yoshiki Mukudai, Harumi Kawaki, Seiji Kondo, Takanori Eguchi, Kumi Sumiyoshi, Toshihiro Ohgawara, Tsuyoshi Shimo, Masaharu Takigawa

5. The CCN Genes as the “Master” Regulators of Angiogenesis, Vasculogenesis, Fibrogenesis and Cell Differentiation/Fate Specification in Mechanical Force-Driven Developmental Processes and Pathological Events
Mary Hanna, Brahim Chaqour

6. A Monoclonal Antibody Approach to CCN5 Domain Analysis
Lan Wei, Frank McKeon, Joshua W. Russo, Joan Lemire, John Castellot

7. Matricellular Protein CCN2 Produced by Tubular Epithelial Cells Plays a Pivotal Role in Renal Fibrogenesis
Hirokazu Okada, Tsutomu Inoue, Hiromichi Suzuki

8. Cooperative Regulation of Cell Proliferation and Differentiation by CCN2 and CCN3
Masaharu Takigawa, Harumi Kawaki, Satoshi Kubota, Karen M. Lyons, Bernard Perbal

9. The Role of CCN3 in Mesenchymal Stem Cells
Ken-Ichi Katsube

10. Role of Connective Tissue Growth Factor in Cardiac Fibrosis
Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain

11. Gene Expression of CCN Family Members in Young and Aged Human Skin In Vivo
Taihao Quan, Sharon Shin, Zhaoping Qin, Gary J. Fisher

12. Global Expression Profiling Reveals a Role for CTGF/CCN2 in Lactogenic Differentiation of Mouse Mammary Epithelial Cells
Weihan Wang, Cynthia Jose, Nicholas Kenney, Bethanie Morrison, Mary Lou Cutler

13. CCN3 (NOV): A Negative Regulator of CCN2 (CTGF) Activity and an Endogenous Inhibitor of Fibrosis in Experimental Diabetic Nephropathy
Bruce. L. Riser, Feridoon Najmabadi, Bernard Perbal, Jo Ann Rambow, Melisa L. Riser, Ernest Sukowski, Herman Yeger, Sarah C. Riser, Darryl R. Peterson

14. Inhibitors of Connective Tissue Growth Factor (CCN2)-Mediated Fibrogenesis: Underlying Mechanisms and Prospects for Anti-fibrotic Therapy
David R. Brigstock

15. CCN3 Promotes Melanoma Progression by Regulating Integrin Expression, Adhesion and Apoptosis Induced by Cytotoxic Drugs
Viviana Vallacchi, Maria Daniotti, Annamaria Filippo, Licia Rivoltini, Bernard Perbal, Monica Rodolfo

16. CCN3: A NOVel Growth Factor in Leukaemia
Lynn McCallum, Alexandra E Irvine

17. Prognostic Relevance of CCN3 in Bone Sarcomas
Bernard Perbal, Noureddine Lazar, Diana Zambelli, Monia Zuntini, Massimo Serra, Jose Antonio Lopez-Guerrero, Antonio Llombart-Bosch, Piero Picci, Katia Scotlandi

18. CCN6 Regulates Breast Cancer Growth and Invasion Through Modulation of IGF Signaling and Epithelial to Mesenchymal Transition
Anupama Pal*, Wei Huang*, Celina G. Kleer

19. Novel Transcriptional Regulation of CCN2/CTGF by Nuclear Translocation of MMP3
Takanori Eguchi, Satoshi Kubota, Kazumi Kawata, Yoshiki Mukudai, Junji Uehara, Toshihiro Ohgawara, Soichiro Ibaragi, Akira Sasaki, Takuo Kuboki, Masaharu Takigawa

Avainsanat: Biomedicine, Biomedicine general, Gene Function, Molecular Medicine, Protein Science, Cell Biology