DNA Replication, Recombination, and Repair

Part I. DNA Replication

1. Molecular Mechanism of DNA Replication
Hiroyuki Araki

2. Characteristics of Metazoan DNA Replication Origins
James R. A. Hutchins, Antoine Aze, Philippe Coulombe, Marcel Méchali

3. DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication
Motoshi Hayano, Seiji Matsumoto, Hisao Masai

Part II. DNA Recombination

4. Mechanism of Homologous Recombination
Marek Sebesta, Lumir Krejci

5. Regulation of Recombination by Chromatin
Takatomi Yamada, Kunihiro Ohta

6. Homologous Recombination During Meiosis
Drew Thacker, Scott Keeney

Part III. DNA Repair

7. DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair
Wataru Sakai, Kaoru Sugasawa

8. The Fanconi Anemia Pathway and Interstrand Cross-Link Repair
Masamichi Ishiai, Junya Tomida, Akiko Itaya, James Hejna, Minoru Takata

9. The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective
Gondichatnahalli M. Lingaraju, Kerstin Böhm, Julius Rabl, Simone Cavadini, Eric S. Fischer, Susanne A. Kassube, Nicolas H. Thomä

Part IV. Genome Instability and Mutagenesis

10. Genome Instability of Repetitive Sequence: Lesson from the Ribosomal RNA Gene Repeat
Takehiko Kobayashi

11. Translesion DNA Synthesis and Damage Tolerance Pathways
Yuji Masuda, Fumio Hanaoka, Chikahide Masutani

12. Mismatch Repair
Richard Fishel, Jong-Bong Lee

13. Nonhomologous End-Joining
Dik C. Gent, Hanna IJspeert, Mirjam Burg

Part V. Chromosome Dynamics and Functions

14. Centromeric Chromatin and Kinetochore Assembly in Vertebrate Cells
Tatsuo Fukagawa

15. CST Complex and Telomere Maintenance
Fuyuki Ishikawa

Part VI. Cell Cycle and Checkpoints

16. Signaling of DNA Replication Stress Through the ATR Checkpoint
Bunsyo Shiotani, Lee Zou

17. Spindle Assembly Checkpoint: Its Control and Aberration
Kazuhiko Uchida, Toru Hirota

18. Molecular Insights into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer
Yoshikazu Johmura, Makoto Nakanishi

Part VII. Interplay with Transcription and Epigenetic Regulation

19. DNA Replication and Histone Modification
Hiroshi Kimura, Yuko Sato

20. Establishment and Maintenance of DNA Methylation
Shoji Tajima, Hironobu Kimura, Isao Suetake

21. Active DNA Demethylation in Development, Human Disease, and Cancer
Rossella Tricarico, Alfonso Bellacosa

Avainsanat: Life Sciences, Cell Biology, Biochemistry, general, Pathology, Cytogenetics