TGF-β in Human Disease

Part I. Introduction

1. Transforming Growth Factor-β Signaling
Carl-Henrik Heldin

2. TGF-β Signaling in Stem Cell Fate Determination
Zhongwei Li, Danny Huylebroeck, Ye-Guang Chen

3. Emerging Roles of TGF-β Co-receptors in Human Disease
Alison E. Meyer, Karthikeyan Mythreye, Gerard C. Blobe

Part II. Cancer, Fibrosis, and Inflammation

4. TGF-β in Cancer Stem Cells
Hiroaki Ikushima, Kohei Miyazono

5. TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition
Laurent Bartholin, David F. Vincent, Ulrich Valcourt

6. TGF-β as Tumor Suppressor: Lessons from Mouse Models
Ulrich Valcourt, David F. Vincent, Laurent Bartholin

7. The Multifunctional Roles of TGF-β in Navigating the Metastatic Cascade
Michael K. Wendt, William P. Schiemann

8. TGF-β Signaling in Leukemogenesis
Kazuhito Naka, Atsushi Hirao

9. TGF-β in Skin Cancer and Fibrosis
Gangwen Han, Zheyi Han, Xiao-Jing Wang

10. The Role of TGF-β in Cutaneous Melanoma Biology
Delphine Javelaud, Alain Mauviel

11. The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis
Isabel Fabregat, Patricia Sancho

12. TGF-β and Inhibitory Smads in Inflammation
Seong-Jin Kim, Seok Hee Park

Part III. Cardiovascular Diseases

13. TGF-β and Cardiovascular Disorders
Laurens A. Meeteren, Marie-José Goumans, Peter ten Dijke

14. TGF-β Signaling in Physiological and Pathological Angiogenesis
Sara I. Cunha, Kristian Pietras

15. TGF-β Signaling Pathway and MicroRNAs in Cardiovascular Disease
Nisha Marathe, Akiko Hata

Part IV. Other Diseases

16. TGF-β and Genetic Skeletal Diseases
Shiro Ikegawa, Mitsuko Nakashima, Naomichi Matsumoto

17. TGF-β in Brain Disorders
Kerstin Krieglstein

18. TGF-β and Metabolic Homeostasis
Grace Bennett, Sushil G. Rane

Part V. Disease Prognosis and Therapy

19. Targeting Pro-Angiogenic TGF-β Signaling in the Tumor Microenvironment
Kristian Pietras, Sara I. Cunha

Avainsanat: Life Sciences, Cytokines and Growth Factors, Cell Biology, Cancer Research