The Hygiene Hypothesis and Darwinian Medicine

1. Introduction: The changing microbial environment, Darwinian medicine and the hygiene hypothesis
Graham A. W. Rook

2. The paleolithic disease-scape, the hygiene hypothesis, and the second epidemiological transition
George J. Armelagos

3. Immunoregulation by microbes and parasites in the control of allergy and autoimmunity
Rick M. Maizels, Ursula Wiedermann

4. Hepatitis A virus, TIM-1 and allergy
Dale T. Umetsu, Rosemarie H. DeKruyff

5. Linking lifestyle with microbiota and risk of chronic inflammatory disorders
Fergus Shanahan

6. Soil bacteria, nitrite and the skin
David R. Whitlock, Martin Feelisch

7. The hygiene hypothesis and allergic disorders
Paolo M. Matricardi, Eckard Hamelmann

8. Multiple sclerosis
Jorge Correale

9. Inflammatory bowel disease and the hygiene hypothesis: an argument for the role of helminths
David E. Elliott, Joel V. Weinstock

10. The hygiene hypothesis and Type 1 diabetes
Anne Cooke

11. The hygiene hypothesis and affective and anxiety disorders
Graham A. W. Rook, Christopher A. Lowry

12. Immune regulation in atherosclerosis and the hygiene hypothesis
Hafid Ait-Oufella, Alain Tedgui, Ziad Mallat

13. The ‘delayed infection’ (aka ‘hygiene’) hypothesis for childhood leukaemia
Mel Greaves

14. Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis?
W. Sue T. Griffin, Robert E. Mrak

15. Alternative and additional mechanisms to the hygiene hypothesis
Margo C. Honeyman, Leonard C. Harrison

Avainsanat: Biomedicine, Immunology, Infectious Diseases, Medical Microbiology, Cell Biology