Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Section A. Bipolar depression: Clinical phenotype and course of illness

1. The history of bipolar disorders
Andreas Marneros

2. The clinical diagnosis of bipolar depression
Gordon B. Parker, Kathryn Fletcher

3. Course and outcome of bipolar disorder — focusing on depressive aspects
Tamas Treuer, Mauricio Tohen

4. Suicide and bipolar disorder
Zoltán Rihmer

Section B. Bipolar depression: Neurobiology

5. The genetic basis of bipolar disorder
Thomas G. Schulze, Francis J. McMahon

6. Understanding the neurobiology of bipolar depression
Jun-Feng Wang, L. Trevor Young

7. Non-pharmacological treatments and chronobiological aspects of bipolar disorder: implications for novel therapeutics
Wallace C. Duncan

8. Neuroimaging studies of bipolar depression: therapeutic implications
Jonathan Savitz, Wayne C. Drevets

Section C. Acute and long-term treatment of bipolar disorder

9. Pharmacological treatment of acute bipolar depression
Gary S. Sachs, Louisa G. Sylvia, Hannah G. Lund

10. Pharmacological treatment of the maintenance phase of bipolar depression: focus on relapse prevention studies and the impact of design on generalizability
Keming Gao, David E. Kemp, Joseph R. Calabrese

11. Non-pharmacological somatic treatments for bipolar depression
Harold A. Sackeim

12. Potential novel treatments for bipolar depression
Carlos A. Zarate, Husseini K. Manji

Section D. Treatment of bipolar disorder in special populations

13. Late-onset bipolar disorder
John L. Beyer, K. Ranga R. Krishnan

14. Treatment of childhood-onset bipolar disorder
Robert L. Findling

15. Treatment of bipolar disorder during and after pregnancy
Patricia Roy, Jennifer L. Payne

16. Conclusion
Carlos A. Zarate, Husseini K. Manji

Avainsanat: Biomedicine, Pharmacology/Toxicology, Psychopharmacology, Psychiatry, Neurosciences, Cell Biology