Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

Part I.Historical perspective on capsaicin and its receptor

1. Hot peppers, pain and analgesics
János Szolcsányi

Part II.Molecular and cellular properties of vanilloid receptors

2. Structural determinants of TRPV1 functionality
Makoto Tominaga

3. TRPV1 distribution and regulation
Janet Winter

Part III.Pharmacology and physiology of vanilloid receptors

4. Insights into TRPV1 pharmacology provided by non-capsaicin ligands
Peter M. Blumberg, Derek C. Braun, Noemi Kedei, Jozsef Lazar, Vladimir Pavlyukovets, Larry V. Pearce

5. Endocannabinoids and vanilloid TRPV1 receptors
Ruth A. Ross

6. Vanilloid receptor-mediated hyperalgesia and desensitization
Zoltán Sándor, Arpad Szallasi

7. Capsaicin in human experimental pain models of skin, muscle and visceral sensitization
Lars Arendt-Nielsen, Ole K. Andersen

Part IV.Vanilloid receptor involvement in disease states

8. TRPV1 in gut function, abdominal pain and functional bowel disorders
Peter Holzer

9. TRPV1 in the airways
Maria G. Belvisi, Peter J. Barnes

Part V.Therapeutic potential of vanilloid agonists and antagonists

10. TRPV1 agonist-based therapies: mechanism of action and clinical prospects
Keith R. Bley, Annika B. Malmberg

11. TRPV1 agonist therapies in bladder diseases
Francisco Cruz, Carlos Silva, Paulo Dinis

12. TRPV1 antagonists and chronic pain
Kenneth J. Valenzano, James D. Pomonis, Katharine Walker

DRM-restrictions

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Avainsanat: MEDICAL / Public Health MED078000