Sphingolipids: Basic Science and Drug Development

Part I. Basic Mechanisms

1. The Genetics of Sphingolipid Hydrolases and Sphingolipid Storage Diseases
Edward H. Schuchman, Calogera M. Simonaro

2. Sphingolipids and Membrane Domains: Recent Advances
Salvatore Chiantia, Erwin London

3. Sphingolipid Metabolism and Neutral Sphingomyelinases
Michael V. Airola, Yusuf A. Hannun

4. Acid Sphingomyelinase
Brian Henry, Regan Ziobro, Katrin Anne Becker, Richard Kolesnick, Erich Gulbins

5. Ceramide Synthases: Reexamining Longevity
Joo-Won Park, Yael Pewzner-Jung

6. Membrane Channels Formed by Ceramide
Marco Colombini

7. Genetic Disorders of Simple Sphingolipid Metabolism
Virginie Albinet, Marie-Lise Bats, Carmen Bedia, Frédérique Sabourdy, Virginie Garcia, Bruno Ségui, Nathalie Andrieu-Abadie, Thorsten Hornemann, Thierry Levade

8. The Role of Ceramide-1-Phosphate in Biological Functions
L. Alexis Hoeferlin, Dayanjan S. Wijesinghe, Charles E. Chalfant

Part II. Drug Development

9. Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
Johannes Kornhuber, Philipp Tripal, Erich Gulbins, Markus Muehlbacher

10. Novel Drugs Targeting Sphingolipid Metabolism
Krishna P. Bhabak, Christoph Arenz

11. The Therapeutic Potential of Nanoscale Sphingolipid Technologies
Jody L. Hankins, Ushma A. Doshi, Jeremy K. Haakenson, Megan M. Young, Brian M. Barth, Mark Kester

12. Novel Chemotherapeutic Drugs in Sphingolipid Cancer Research
Daniel Canals, Yusuf A. Hannun

13. Pharmacology of the Sphingosine-1-Phosphate Signalling System
Dagmar Meyer Heringdorf, Katja Ihlefeld, Josef Pfeilschifter

Avainsanat: Biomedicine, Pharmacology/Toxicology, Membrane Biology, Cell Biology, Molecular Medicine