Heart Rate and Rhythm

1. Cardiac Ion Channels and Heart Rate and Rhythm
Onkar Nath Tripathi

2. Ionic Basis of the Pacemaker Activity of SA Node Revealed by the Lead Potential Analysis
Yukiko Himeno, Chae Young Cha, Akinori Noma

3. The “Funny” Pacemaker Current
Andrea Barbuti, Annalisa Bucchi, Raffaella Milanesi, Georgia Bottelli, Alessia Crespi, Dario DiFrancesco

4. Novel Perspectives on Cardiac Pacemaker Regulation: Role of the Coupled Function of Sarcolemmal and Intracellular Proteins
Victor A. Maltsev, Tatiana M. Vinogradova, Edward G. Lakatta

5. Pacemaker Activity of the SA Node: Insights from Dynamic-Clamp Experiments
Ronald Wilders, Antoni C. G. Ginneken, Arie O. Verkerk

6. Heart Rate Variability: Molecular Mechanisms and Clinical Implications
Kishore K. Deepak

7. Mechano-Electric Feedback in the Heart: Effects on Heart Rate and Rhythm
T. Alexander Quinn, Rebecca A. Bayliss, Peter Kohl

8. A Historical Perspective on the Development of Models of Rhythm in the Heart
Penelope J. Noble, Denis Noble

9. Simulation of Cardiac Action Potentials
Jonathan D. Moreno, Colleen E. Clancy

10. Development of Pacemaker Activity in Embryonic and Embryonic Stem Cell-Derived Cardiomyocytes
Huamin Liang, Michael Reppel, Ming Tang, Jürgen Hescheler

11. Molecular Basis of the Electrical Activity of the Atrioventricular Junction and Purkinje Fibres
Halina Dobrzynski, Oliver Monfredi, Ian D. Greener, Andrew Atkinson, Shin Inada, Mary-Anne Taube, Joseph Yanni, Olga Fedorenko, Peter Molenaar, Robert H. Anderson, Igor R. Efimov, Mark R. Boyett

12. Molecular Basis and Genetic Aspects of the Development of the Cardiac Chambers and Conduction System: Relevance to Heart Rhythm
Martijn L. Bakker, Vincent M. Christoffels, Antoon F. M. Moorman

13. Role of the T-Tubules in the Response of Cardiac Ventricular Myocytes to Inotropic Interventions
C. H. Orchard, F. Brette, A. Chase, M. R. Fowler

14. An Overview of Spiral- and Scroll-Wave Dynamics in Mathematical Models for Cardiac Tissue
Rupamanjari Majumder, Alok Ranjan Nayak, Rahul Pandit

15. Post-infarction Remodeling and Arrhythmogenesis: Molecular, Ionic, and Electrophysiological Substrates
Nabil El-Sherif

16. The Role of Intracellular Ca2+ in Arrhythmias in the Postmyocardial Infarction Heart
Wen Dun, Henk Keurs, Penelope A. Boyden

17. Molecular and Biochemical Characteristics of the Intracellular Ca2+ Handling Proteins in the Heart
Yasser Abdellatif, Vijayan Elimban, Delfin Rodriguez-Leyva, Naranjan S. Dhalla

18. Pharmacological Modulation and Clinical Implications of Sarcolemmal Ca2+-Handling Proteins in Heart Function
Yasser Abdellatif, Adriana Adameova, Naranjan S. Dhalla

19. Calmodulin Kinase II Regulation of Heart Rhythm and Disease
Thomas J. Hund

20. MicroRNA and Pluripotent Stem Cell-Based Heart Therapies: The Electrophysiological Perspective
Ellen Poon, Deborah K. Lieu, Ronald A. Li

21. Intracellular Calcium Handling and Inherited Arrhythmogenic Diseases
Nicola Monteforte, Carlo Napolitano, Raffaella Bloise, Silvia G. Priori

22. Molecular Mechanisms of Voltage-Gated Na+ Channel Dysfunction in LQT3 Syndrome
Thomas Zimmer, Klaus Benndorf

23. The Short QT Syndrome
Jules C. Hancox, Mark J. McPate, Aziza Harchi, Rona S. Duncan, Chris E. Dempsey, Harry J. Witchel, Ismail Adeniran, Henggui Zhang

24. Adrenergic Regulation and Heritable Arrhythmias: Key Roles of the Slowly Activating Heart I
Ks Potassium Channel
David Y. Chung, Kevin J. Sampson, Robert S. Kass

25. Defects in Ankyrin-Based Protein Targeting Pathways in Human Arrhythmia
Hjalti Gudmundsson, Francis Jareczek, Peter J. Mohler

26. Genetically Modified Mice: Useful Models to Study Cause and Effect of Cardiac Arrhythmias?
Gregor Sachse, Martin Kruse, Olaf Pongs

27. Genetics of Atrial Fibrillation
Saagar Mahida, Michiel Rienstra, Moritz F. Sinner, Steven A. Lubitz, Patrick T. Ellinor, Stefan Kääb

28. The Role of Gap Junctions in Impulse Propagation in the Heart: New Aspects of Arrhythmogenesis and New Antiarrhythmic Agents Targeting Gap Junctions
Stefan Dhein, Joanna Jozwiak, Anja Hagen, Thomas Seidel, Anna Dietze, Aida Salameh, Martin Kostelka, Friedrich Wilhelm Mohr

29. Possible Mechanisms of the Acute Ischemia-Induced Ventricular Arrhythmias: The Involvement of Gap Junctions
Ágnes Végh, Rita Papp

30. Role of NCX1 and NHE1 in Ventricular Arrhythmia
András Tóth, András Varró

31. TRP Channels in Cardiac Arrhythmia: Their Role During Purinergic Activation Induced by Ischemia
Guy Vassort, Julio Alvarez

32. Cardiac Aquaporins: Significance in Health and Disease
Tanya L. Butler, David S. Winlaw

33. Ion Channels as New Drug Targets in Atrial Fibrillation
Ursula Ravens

34. hERG1 Channel Blockers and Cardiac Arrhythmia
Michael C. Sanguinetti, Matthew Perry

35. Preclinical Drug Safety and Cardiac Ion Channel Screening
Zhi Su, Gary Gintant

36. QT Prolongation Is a Poor Predictor of Proarrhythmia Liability: Beyond QT Prolongation!
Luc M. Hondeghem

37. K Channel Openers as New Anti-arrhythmic Agents
Nathalie Strutz-Seebohm, Guiscard Seebohm

Avainsanat: Biomedicine, Molecular Medicine, Human Physiology, Pharmacology/Toxicology, Cardiology