Laron Syndrome - From Man to Mouse

1. History of the Israeli Cohort of Laron Syndrome Patients (1958–2009)
Zvi Laron

2. Early Investigations: Characterizations of the Circulating Growth Hormone
Zvi Laron

3. Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome
Zvi Laron

4. Diagnosis of Laron Syndrome
Zvi Laron

5. Genetic Aspects
Orit Shevah, Zvi Laron

6. Clinical Evaluation
Zvi Laron

7. Perinatal Development in Laron Syndrome
Zvi Laron, Rivka Kauli

8. Linear Growth Pattern of Untreated Laron Syndrome Patients
Zvi Laron, Rivka Kauli

9. Head Shape, Size, and Growth of Untreated Patients with Laron Syndrome
Zvi Laron, Rivka Kauli

10. Sexual Development in Patients with Laron Syndrome
Zvi Laron, Rivka Kauli

11. Sex Hormone Binding Proteins and Sex Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome
Zvi Laron, Rivka Kauli

12. The Adipose Tissue in Patients with Laron Syndrome
Zvi Laron

13. Investigations to Determine the Cause of Obesity in Patients with Laron Syndrome
Zvi Laron, Shira Ginsberg, Nahum Vaisman

14. Nonalcoholic Fatty Liver Disease (Nafld) in Patients with Laron Syndrome
Zvi Laron

15. Serum Lipids in Patients with Laron Syndrome
Zvi Laron

16. Adiponectin and Leptin in Laron Syndrome
Zvi Laron, Hannah Kanety

17. Muscle Force and Endurance in Untreated Adult and IGF-I Treated Children with Laron Syndrome
Zvi Laron

18. Bone Mineral Density in Untreated and IGF-I or Alendronate-Treated Patients with Laron Syndrome
Zvi Laron

19. Muscle–Bone Relationship in Patients with Laron Syndrome
Yoram Epstein, Amir Hadid, Zvi Laron, Daniel S. Moran, Nahum Vaisman

20. Imaging Findings in Laron Syndrome
Liora Kornreich, Zvi Laron

21. Ocular Findings in Laron Syndrome
Dan H. Bourla, Dov Weinberger

22. Hearing in Patients with Laron Syndrome
Zvi Laron, Omer Zarchi, Joseph Attias

23. The Teeth in Patients with Laron Syndrome
Zvi Laron

24. Hair, Skin, and Nails in Patients with Laron Syndrome
Zvi Laron

25. Hand, Foot, and Organ Size and Growth in Untreated and IGF-I Treated Patients with Laron Syndrome
Zvi Laron, Aviva Silbergeld

26. Lifelong Serum Growth Hormone Levels in Patients with Laron Syndrome
Zvi Laron, Orly Efros

27. IGF-I Binding Proteins in Laron Syndrome
Zvi Laron

28. Serum Prolactin in Untreated and IGF-I Treated Patients with Laron Syndrome
Zvi Laron, Orly Efros

29. Thyroid Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome
Zvi Laron, Rivka Kauli

30. Insulin Secretion and Carbohydrate Metabolism in Patients with Laron Syndrome: From Hypoglycemia to Diabetes Mellitus
Zvi Laron

31. Liver Enzymes in Patients with Laron Syndrome
Zvi Laron, Tsvia Karmon

32. The Hematopoietic System in Patients with Laron Syndrome
Zvi Laron

33. Cardiovascular Aspects in Laron Syndrome Patients
Mickey Scheinowitz, Micha S. Feinberg, Michael Shechter, Zvi Laron, Rivka Kauli

34. Kidney Functions in Untreated and IGF-I Treated Patients with Laron Syndrome
Zvi Laron

35. Sleep and Sleep Disorders in Patients with Laron Syndrome
Zvi Laron, Rivka Kauli, Eyal Rosenzweig

36. Neurological Aspects in Laron Syndrome
Zvi Laron

37. Orthopedic Problems in Laron Syndrome
Zvi Laron, Rivka Kauli

38. Psychological Aspects in Patients with Laron Syndrome
Zvi Laron

39. Adjustment and Rehabilitation Problems of Children, Adolescents, and Adults with Laron Syndrome
Zvi Laron

40. Laron Syndrome Patients with Congenital IGF-I Deficiency Seem Protected from Malignant Diseases
Zvi Laron, Rachel Steuerman, Orit Shevah

41. Lifespan and Mortality of Patients with Laron Syndrome
Zvi Laron

42. IGF-I Treatment of Patients with Laron Syndrome
Zvi Laron

43. IGF-I Stimulation of Head Growth in Patients with Laron Syndrome
Zvi Laron

44. Effects of Long-Term Administration of IGF-I on the Adipose Tissue and Carbohydrate Metabolism in Children with Laron Syndrome
Zvi Laron

45. Comparison of the Growth Promoting Response of IGF-I in Children with Laron Syndrome with that of hGH in Children with Isolated GH Deficiency
Zvi Laron

46. IGF-I Treatment of Adult Patients with Laron Syndrome
Zvi Laron

47. Adverse Effects Encountered During IGF-I Treatment of Patients with Laron Syndrome
Zvi Laron

48. Summary of the Clinical History: The Laron Syndrome Clock
Zvi Laron

49. The Laron Mouse
John J. Kopchick, John D. Blischak

50. Role of GH/IGF-I Deficiency in Aging
Edward O. List

51. Body Composition, Adipose Tissue, and Energy Balance
Darlene E. Berryman

52. Metabolism and Metabolic Regulation
Lucila Sackmann-Sala, D. R. Bailey Miles, John J. Kopchick

53. Skeletal Muscle
Juan Ding, John J. Kopchick

54. Cardiac Function in GHR–/– Mice
Diana Cruz-Topete, John J. Kopchick

55. Bone
Shigeru Okada, Jacob Wright-Piekarski

56. GHR Knockout and the CNS
Elahu S. Gosney, John J. Kopchick

57. Cancer
Brian D. Bower, John J. Kopchick

58. Reproduction
Bruce Kelder

59. Conclusions and Future Studies
John J. Kopchick, Hiroyoshi Tanda, Darlene E. Berryman, Zvi Laron

Avainsanat: Medicine & Public Health, Pediatrics, Endocrinology, Internal Medicine, Human Genetics, Molecular Medicine, Human Physiology