Targeted Therapies in Cancer

Part I. Prediction of Tumor Behavior

1. Beyond Typing and Grading: Target Analysis in Individualized Therapy as a New Challenge for Tumour Pathology
Hans H. Kreipe, Reinhard Wasielewski

2. Oncogenic Signaling Pathways and Deregulated Target Genes
Reinhold Schäfer, Anja Schramme, Oleg I. Tchernitsa, Christine Sers

3. Predictive Pathology of Cytostatic Drug Resistance and New Anti-cancer Targets
Manfred Dietel

4. Prediction of Response to Neoadjuvant Chemotherapy in Carcinomas of the Upper Gastrointestinal Tract
Heinz Höfler, Rupert Langer, Katja Ott, Gisela Keller

5. Resistance-Associated Signatures in Breast Cancer
Balázs Györffy

6. Resistance to Chemotherapy in Ovarian Carcinoma
Hermann Lage, Carsten Denkert

7. Clinical, Biological, and Molecular Aspects of Metastasis in Colorectal Cancer
Ulrike Stein, Peter M. Schlag

8. Prediction of Efficacy and Side Effects of Chemotherapy in Colorectal Cancer
Jan Stoehlmacher

9. Proteomic Expression Profiling of Breast Cancer
Hans Neubauer, Tanja Fehm, Christina Schütz, Runa Speer, Erich Solomayer, André Schrattenholz, Michael A. Cahill, Raffael Kurek

Part II. Targeted Therapy and Clinical Applications

10. Targeted Therapy and Blood-Brain Barrier
Agnieszka Korfel, Eckhard Thiel

11. Cetuximab: Appraisal of a Novel Drug Against Colorectal Cancer
Bert Hildebrandt, Philipp Coutre, Annett Nicolaou, Konrad Kölble, Hanno Riess, Bernd Dörken

12. C-kit, GIST, and Imatinib
Jan Siehl, Eckhard Thiel

13. Antibody Therapy in Non-Hodgkin’s Lymphoma: The Role of Rituximab, 90Y-Ibritumomab Tiuxetan, and Alemtuzumab
Thomas Fietz, Eckhard Thiel

14. Molecular and Clinical Aspects of Proteasome Inhibition in the Treatment of Cancer
Ivana Zavrski, Christian Jakob, Martin Kaiser, Claudia Fleissner, Ulrike Heider, Orhan Sezer

15. Individualized Target Therapy of Malignant Lymphomas: An Outlook
Ioannis Anagnostopoulos

16. Antiangiogenesis, Anti-VEGF(R) and Outlook
Iver Petersen

17. Morphological Detection of Hormone and Growth Factor Receptors in Breast Cancer
Konrad Kölble

Part III. Prospects for Development

18. Antigen-Specific Cancer Vaccines
Ulrich Keilholz

19. Therapeutic Vaccination for the Treatment of Malignant Melanoma
Peter Walden

20. Monoclonal and Recombinant Antibodies with T Cell Receptor-Like Reactivity
Andreas Ziegler, Pierre G. Coulie, Barbara Uchanska-Ziegler

21. New Molecular Therapy Targets in Acute Myeloid Leukemia
Utz Krug, Hubert Serve, Carsten Müller-Tidow, Rolf M. Mesters, Björn Steffen, Thomas Büchner, Wolfgang E. Berdel

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