Beyreuther, Konrad
Alzheimer: 100 Years and Beyond
1. Concerning a unique disease of the cerebral cortex
Alois Alzheimer
2. The history of Alois Alzheimer’s first case Auguste D.
Konrad Maurer
3. Alois Alzheimer and the beginnings of research into Alzheimer’s disease
Ralf Dahm
4. Alois Alzheimer and the myth of the pioneer
Yves Christen
5. Alzheimer’s Disease at mid-Century (1927–1977) and a little more
Robert D. Terry
6. A chapter in the development on Alzheimer’s disease research
Zaven S. Khachaturian
7. Anatomical changes underlying dementia in Alzheimer’s disease
Bradley T. Hyman
8. Staging of cortical neurofibrillary inclusions of the Alzheimer’s type
Heiko Braak, Kelly Tredici
9. Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer’s disease
Charles Duyckaerts, Jean-Jacques Hauw
10. Presenile forms of Alzheimer’s disease in 2006
Michel Poncet, Olivier Felician, Jean-François Pellissier
11. The cholinergic deficit in Alzheimer’s disease
Peter Davies
12. Acetylcholine in AD: Expectations meet reality
John H. Growdon
13. The Discovery of ß Amyloid
Cai’ne W. Wong
14. Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aß amyloid of Alzheimer’s disease
Colin L Masters, Konrad Beyreuther
15. The Amyloid Hypothesis: history and alternatives
John Hardy
16. Segregation of a missense mutation in the amyloid ß-protein precursor gene with familial Alzheimer’s disease
Alison Goate
17. From the amyloid ß protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid ß (A4) precursor protein (APP)
Rudolph E. Tanzi
18. Commentary on “Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice”
Karen Hsiao Ashe
19. Vision for the future
Donald L. Price, Tong Li, Fiona M. Laird, Mohamed Farah, Alena V. Savonenko, Michael Lee, Juan Troncoso, Philip C. Wong
20.
Steven G. Younkin
21. Amyloid precursor protein, Alzheimer’s disease, and Down’s syndrome
Edward H. Koo
22. Catabolism of amyloid ß peptide and pathogenesis of sporadic Alzheimer’s disease: towards understanding the underlying mechanisms
Takaomi C. Saido
23. Synaptic activity, amyloid-ß and Alzheimer’s disease
John R. Cirrito, David M. Holtzman
24. Molecular pathogenesis of Alzheimer’s disease in human peripheral cells: platelets show it all!
Elena Marcello, Barbara Borroni, Fabrizio Gardoni, Alessandro Padovani, Monica Luca
25. The neuronal origin hypothesis of cerebral amyloid angiopathy
Mathias Jucker
26. A neuropathologist and Alzheimer genetics
Jean-François Foncin
27. Genetics, molecular biology, and animal modeling of Alzheimer’s disease
P. H. St George-Hyslop, P. E. Fraser, D. Westaway, J. McLaurin, E. Rogaeva, G. Schmitt-Ulms, A. Tandon, H. T. J Mount, J. Robertson, C. Bergeron
28. The genetic Alzheimer-frontotemporal dementia spectrum
Christine Broeckhoven
29. Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke
Blas Frangione, Jorge Ghiso
30. Physiological generation of Amyloid ß-peptide and its Consequences for Alzheimer’s disease research
Christian Haass
31. Activation of a-secretase as an approach for treatment of Alzheimer’s disease
Falk Fahrenholz
32. Challenges to the enigma of ?-secretase and to Alzheimer’s disease
Takeshi Iwatsubo
33. Targeting ?-Secretase for Alzheimer’s Disease
Michael S. Wolfe
34. The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer’s Disease
Bart Strooper
35. Identification of ß-secretase
Martin Citron
36. Apolipoprotein E and Alzheimer’s disease: A brief retrospective
Allen D. Roses
37. Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer’s disease
Judes Poirier
38. The Alzheimer tangle — 100 years on.
Michel Goedert, Maria Grazia Spillantini, Bernardino Ghetti, R. Anthony Crowther, Aaron Klug
39. Immunological demonstration of tau protein in neurofibrillary tangles
Jean-Pierre Brion
40. Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation
Khalid Iqbal, Inge Grundke-Iqbal
41. The natural and molecular history of Alzheimer’s disease: Tau is part of the story
André Delacourte
42. Tau focused drug discovery for Alzheimer’s disease and related Neurodegenerative Tauopathies
Virginia M. -Y. Lee, John Q. Trojanowski
43. Ubiquitin is a component of paired helical filaments in Alzheimer’s disease
Yasuo Ihara
44. Influence of tau on neuronal traffic mechanisms
E. -M. Mandelkow, E. Thies, J. Biernat, E. Mandelkow
45. The Search for structure of tau and paired helical filaments
E. Mandelkow, M. Bergen, A. Marx, J. Biernat, E. -M. Mandelkow
46. The Changing landscape of Alzheimer’s disease: From Insoluble to Soluble and from Pathogen to Protector
Mark A. Smith, George Perry
47. Molecular and cellular pathways towards and away from Alzheimer’s disease
Mark P. Mattson
48. Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging
Jean François Dartigues
49. Hippocampal imaging in the early diagnosis of AD, 1988 to 2006
Mony J. Leon
50. Detecting Early-Stage Alzheimer’s Disease in MCI and PreMCI: The value of informants
John C. Morris, Martha Storandt
51. Imaging the pathology of Alzheimer’s disease: Building on a century-Old blueprint
William E. Klunk, Chester A. Mathis
52. How do we test drugs?
Leon J. Thal
53. Inflammation and the lesions of Alzheimer’s disease
Edith G. McGeer, Patrick L. McGeer
54. Aß immunotherapy prevents and Reverses Alzheimer’s disease neuropathology
Dale Schenk, Dora Games, Peter Seubert
55. Immunotherapy of Alzheimer’s disease
Roger M. Nitsch, Christoph Hock
56. “Magic” bullets, shotguns or cocktails to treat or prevent Alzheimer’s disease?
Todd E. Golde
57. The seventh age of man: Solving senility
Dennis J. Selkoe
58. Fondation Ipsen and Alzheimer’s disease: a 20-year relationship
Jacqueline Mervaillie
59. Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research
June Kinoshita, Gabrielle Strobel
DRM-restrictions
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Avainsanat: TECHNOLOGY & ENGINEERING / Biomedical TEC059000
- Tekijä(t)
- Beyreuther, Konrad
- Christen, Yves
- Haass, Christian
- Jucker, Mathias
- Nitsch, Roger M.
- Julkaisija
- Springer
- Julkaisuvuosi
- 2006
- Kieli
- en
- Painos
- 1
- Kategoria
- Terveys, kauneus, muoti
- Tiedostomuoto
- E-kirja
- eISBN (PDF)
- 9783540376521