Beyreuther, Konrad

Alzheimer: 100 Years and Beyond

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ISBN: 9783540376521

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Table of contents

1. Concerning a unique disease of the cerebral cortex
Alois Alzheimer

2. The history of Alois Alzheimer’s first case Auguste D.
Konrad Maurer

3. Alois Alzheimer and the beginnings of research into Alzheimer’s disease
Ralf Dahm

4. Alois Alzheimer and the myth of the pioneer
Yves Christen

5. Alzheimer’s Disease at mid-Century (1927–1977) and a little more
Robert D. Terry

6. A chapter in the development on Alzheimer’s disease research
Zaven S. Khachaturian

7. Anatomical changes underlying dementia in Alzheimer’s disease
Bradley T. Hyman

8. Staging of cortical neurofibrillary inclusions of the Alzheimer’s type
Heiko Braak, Kelly Tredici

9. Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer’s disease
Charles Duyckaerts, Jean-Jacques Hauw

10. Presenile forms of Alzheimer’s disease in 2006
Michel Poncet, Olivier Felician, Jean-François Pellissier

11. The cholinergic deficit in Alzheimer’s disease
Peter Davies

12. Acetylcholine in AD: Expectations meet reality
John H. Growdon

13. The Discovery of ß Amyloid
Cai’ne W. Wong

14. Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aß amyloid of Alzheimer’s disease
Colin L Masters, Konrad Beyreuther

15. The Amyloid Hypothesis: history and alternatives
John Hardy

16. Segregation of a missense mutation in the amyloid ß-protein precursor gene with familial Alzheimer’s disease
Alison Goate

17. From the amyloid ß protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid ß (A4) precursor protein (APP)
Rudolph E. Tanzi

18. Commentary on “Correlative memory deficits, Aß elevation, and amyloid plaques in transgenic mice”
Karen Hsiao Ashe

19. Vision for the future
Donald L. Price, Tong Li, Fiona M. Laird, Mohamed Farah, Alena V. Savonenko, Michael Lee, Juan Troncoso, Philip C. Wong

20. PS1, PS2, and APP mutations that cause Alzheimer’s disease increase Aß42
Steven G. Younkin

21. Amyloid precursor protein, Alzheimer’s disease, and Down’s syndrome
Edward H. Koo

22. Catabolism of amyloid ß peptide and pathogenesis of sporadic Alzheimer’s disease: towards understanding the underlying mechanisms
Takaomi C. Saido

23. Synaptic activity, amyloid-ß and Alzheimer’s disease
John R. Cirrito, David M. Holtzman

24. Molecular pathogenesis of Alzheimer’s disease in human peripheral cells: platelets show it all!
Elena Marcello, Barbara Borroni, Fabrizio Gardoni, Alessandro Padovani, Monica Luca

25. The neuronal origin hypothesis of cerebral amyloid angiopathy
Mathias Jucker

26. A neuropathologist and Alzheimer genetics
Jean-François Foncin

27. Genetics, molecular biology, and animal modeling of Alzheimer’s disease
P. H. St George-Hyslop, P. E. Fraser, D. Westaway, J. McLaurin, E. Rogaeva, G. Schmitt-Ulms, A. Tandon, H. T. J Mount, J. Robertson, C. Bergeron

28. The genetic Alzheimer-frontotemporal dementia spectrum
Christine Broeckhoven

29. Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke
Blas Frangione, Jorge Ghiso

30. Physiological generation of Amyloid ß-peptide and its Consequences for Alzheimer’s disease research
Christian Haass

31. Activation of a-secretase as an approach for treatment of Alzheimer’s disease
Falk Fahrenholz

32. Challenges to the enigma of ?-secretase and to Alzheimer’s disease
Takeshi Iwatsubo

33. Targeting ?-Secretase for Alzheimer’s Disease
Michael S. Wolfe

34. The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer’s Disease
Bart Strooper

35. Identification of ß-secretase
Martin Citron

36. Apolipoprotein E and Alzheimer’s disease: A brief retrospective
Allen D. Roses

37. Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer’s disease
Judes Poirier

38. The Alzheimer tangle — 100 years on.
Michel Goedert, Maria Grazia Spillantini, Bernardino Ghetti, R. Anthony Crowther, Aaron Klug

39. Immunological demonstration of tau protein in neurofibrillary tangles
Jean-Pierre Brion

40. Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation
Khalid Iqbal, Inge Grundke-Iqbal

41. The natural and molecular history of Alzheimer’s disease: Tau is part of the story
André Delacourte

42. Tau focused drug discovery for Alzheimer’s disease and related Neurodegenerative Tauopathies
Virginia M. -Y. Lee, John Q. Trojanowski

43. Ubiquitin is a component of paired helical filaments in Alzheimer’s disease
Yasuo Ihara

44. Influence of tau on neuronal traffic mechanisms
E. -M. Mandelkow, E. Thies, J. Biernat, E. Mandelkow

45. The Search for structure of tau and paired helical filaments
E. Mandelkow, M. Bergen, A. Marx, J. Biernat, E. -M. Mandelkow

46. The Changing landscape of Alzheimer’s disease: From Insoluble to Soluble and from Pathogen to Protector
Mark A. Smith, George Perry

47. Molecular and cellular pathways towards and away from Alzheimer’s disease
Mark P. Mattson

48. Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging
Jean François Dartigues

49. Hippocampal imaging in the early diagnosis of AD, 1988 to 2006
Mony J. Leon

50. Detecting Early-Stage Alzheimer’s Disease in MCI and PreMCI: The value of informants
John C. Morris, Martha Storandt

51. Imaging the pathology of Alzheimer’s disease: Building on a century-Old blueprint
William E. Klunk, Chester A. Mathis

52. How do we test drugs?
Leon J. Thal

53. Inflammation and the lesions of Alzheimer’s disease
Edith G. McGeer, Patrick L. McGeer

54. Aß immunotherapy prevents and Reverses Alzheimer’s disease neuropathology
Dale Schenk, Dora Games, Peter Seubert

55. Immunotherapy of Alzheimer’s disease
Roger M. Nitsch, Christoph Hock

56. “Magic” bullets, shotguns or cocktails to treat or prevent Alzheimer’s disease?
Todd E. Golde

57. The seventh age of man: Solving senility
Dennis J. Selkoe

58. Fondation Ipsen and Alzheimer’s disease: a 20-year relationship
Jacqueline Mervaillie

59. Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research
June Kinoshita, Gabrielle Strobel


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