CD4+CD25+ Regulatory T Cells: Origin, Function and Therapeutic Potential

Part I. Origin and Generation

1. Selection of CD4+CD25+ Regulatory T Cells by Self-Peptides
C. Cozzo, M. A. Lerman, A. Boesteanu, J. Larkin, M. S. Jordan, A. J. Caton

2. The Role of TCR Specificity in Naturally Arising CD25+ CD4+ Regulatory T Cell Biology
C.-S. Hsieh, A. Y. Rudensky

3. Thymic Commitment of Regulatory T Cells Is a Pathway of TCR-Dependent Selection That Isolates Repertoires Undergoing Positive or Negative Selection
A. Coutinho, I. Caramalho, E. Seixas, J. Demengeot

4. Selection and Behavior of CD4+ CD25+ T Cells In Vivo: Lessons from T Cell Receptor Transgenic Models
L. Klein, J. Emmerich, L. d’Cruz, K. Aschenbrenner, K. Khazaie

5. Migration Rules: Functional Properties of Naive and Effector/Memory-Like Regulatory T Cell Subsets
J. Huehn, K. Siegmund, A. Hamann

6. Peripheral Generation and Function of CD4+CD25+ Regulatory T Cells
L. S. Taams, A. N. Akbar

7. Dendritic Cells: Key Cells for the Induction of Regulatory T Cells?
K. Mahnke, A. H. Enk

Part II. Involvement of Disease Models

8. Autoimmune Gastritis Is a Well-Defined Autoimmune Disease Model for the Study of CD4+CD25+ T Cell-Mediated Suppression
R. S. McHugh

9. Regulatory T Cells in Experimental Colitis
M. Gad

10. Autoimmune Ovarian Disease in Day 3-Thymectomized Mice: The Neonatal Time Window, Antigen Specificity of Disease Suppression, and Genetic Control
K. S. K. Tun, Y. Y. Setiady, E. T. Samy, J. Lewis, C. Teuscher

11. Regulatory T Cells in Transplantation Tolerance
H. Waldmann, L. Graca, E. Adams, P. Fairchild, S. Cobbold

12. CD4+CD25+ Regulatory T Cells in Hematopoietic Stem Cell Transplantation
P. Hoffmann, J. Ermann, M. Edinger

13. Naturally Arising CD25+CD4+ Regulatory T Cells in Tumor Immunity
T. Nomura, S. Sakaguchi

14. Phenotypic and Functional Differences Between Human CD4+CD25+ and Type 1 Regulatory T Cells
M. K. Levings, M. G. Roncarolo

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Avainsanat: TECHNOLOGY & ENGINEERING / Biomedical TEC059000