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Brown, Nathan

Scaffold Hopping in Medicinal Chemistry

Brown, Nathan - Scaffold Hopping in Medicinal Chemistry, e-kirja

138,60€

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ISBN: 9783527665167
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Tulostus105 sivua ja lisä sivu kertyy joka 7. tunti, ylärajana 105 sivua
Kopioi leikepöydälle5 poimintoa

This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.
The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following parts contain a general description as well as case studies of the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry.
While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

Avainsanat: Drug Discovery & Development, Scaffold Hopping in Medicinal Chemistry, Nathan Brown, Raimund Mannhold, Hugo Kubinyi, Gerd Folker, chemoinformatics tools, Markush structures and chemical patents, Feature trees (FTrees), XED Forcefields and Fieldstere, Molecular interaction fingerprints, mGluR5 inhibitors

Tekijä(t)
 
 
 
Julkaisija
John Wiley and Sons, Inc.
Julkaisuvuosi
2014
Kieli
en
Painos
1
Sarja
Methods and Principles in Medicinal Chemistry
Sivumäärä
350 sivua
Kategoria
Terveys, kauneus, muoti
Tiedostomuoto
E-kirja
eISBN (ePUB)
9783527665167
Painetun ISBN
9783527333646

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