Mitochondrial Biology and Experimental Therapeutics

Part I. Mitochondrial Biology

1. Introduction: Mitochondria, the Cell Furnaces
Paulo J. Oliveira

2. Mitochondria: Where Are They Coming From?
Mauro Degli Esposti

3. Mitochondrial Dynamics: A Journey from Mitochondrial Morphology to Mitochondrial Function and Quality
David Sebastián, Antonio Zorzano

4. Mitochondria and Ageing
Jose Viña, Consuelo Borras

5. The Mitochondrial Permeability Transition Pore
Claudia Morganti, Massimo Bonora, Luigi Sbano, Giampaolo Morciano, Giorgio Aquila, Gianluca Campo, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton

6. Mitochondrial Regulation of Cell Death
Dawei Liu, Jean-Luc Perfettini, Catherine Brenner

7. Mitochondria in Liver Diseases
Ignazio Grattagliano, Ornella Bari, Domenica Palo, Fabrizio Montecucco, Federico Carbone, Paulo J. Oliveira, David Q.-H. Wang, Piero Portincasa

8. Mitochondria in Liver Regeneration: Energy Metabolism and Posthepatectomy Liver Dysfunction
Henrique Alexandrino, Anabela Rolo, José Guilherme Tralhão, Francisco Castro e Sousa, Carlos Palmeira

9. Mitochondria Remodeling in Cancer
Kenneth J. Dornfeld, Andrew J. Skildum

10. Mitochondria and Kidney Disease
Kenneth E. McMartin

11. Role of Mitochondria in Neurodegenerative Diseases: The Dark Side of the “Energy Factory”
Sónia C. Correia, Paula I. Moreira

12. Mitochondrial Disruption in Cardiovascular Diseases
Edward J. Lesnefsky, Qun Chen, Bernard Tandler, Charles L. Hoppel

13. Drug-Induced Mitochondrial Toxicity
Julie Massart, Annie Borgne-Sanchez, Bernard Fromenty

14. Potential Mechanisms of Mitochondrial DNA Mediated Acquired Mitochondrial Disease
Afshan N. Malik, Hannah S. Rosa

Part II. Mitochondrial Experimental Therapeutics: From the Bench to Industry and Patient

15. The Evolution of Mitochondrial Toxicity Assessment in Industry
James Hynes, Yvonne Will

16. Targeting Mitochondria: The Road to Mitochondriotropic Antioxidants and Beyond
Ricardo Amorim, Sofia Benfeito, José Teixeira, Fernando Cagide, Paulo J. Oliveira, Fernanda Borges

17. Recovering Mitochondrial Function in Patients’ Fibroblasts
Mariusz R. Wieckowski, Alberto Danese, Giampaolo Morciano, Maciej Pronicki, Jerzy Duszynski, Paolo Pinton, Agnieszka Karkucinska-Wieckowska

18. Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity
Jorge Beleza, David Rizo-Roca, António Ascensão, José Magalhães

19. Modulation of Cell Fate by Tauroursodeoxycholic Acid: All Paths Lead to Mitochondria
Susana Solá, Maria F. Ribeiro, Tânia Genebra, Cecília M. P. Rodrigues

20. Pharmacological Targeting of the Mitochondrial Permeability Transition Pore for Cardioprotection
Filomena S. G. Silva, Cláudio F. Costa, Ricardo J. Marques, Paulo J. Oliveira, Gonçalo C. Pereira

21. Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of Mitochondrial Gene Expression
Yuma Yamada, Hideyoshi Harashima

22. Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements
Garth L. Nicolson, Gonzalo Ferreira, Robert Settineri, Rita R. Ellithorpe, Paul Breeding, Michael E. Ash

23. Studies on Mitochondria Directed Plastoquinones
Boris A. Feniouk, Vladimir P. Skulachev

24. Targeted Mitochondrial Genome Elimination
Sandra R. Bacman, Claudia V. Pereira, Carlos T. Moraes

25. Targeting Therapeutic Nucleic Acids into Mitochondria: A Long Challenge
Frédérique Weber-Lotfi, André Dietrich

26. Cell-Penetrating Peptides Targeting Mitochondria
Carmine Pasquale Cerrato, Ülo Langel

27. Mitocans: Mitochondrially Targeted Anti-cancer Drugs
Stepana Boukalova, Katerina Rohlenova, Jakub Rohlena, Jiri Neuzil

28. SkQ1: The Road from Laboratory Bench to the Market
Boris A. Feniouk, Maxim V. Skulachev

Part III. COMIC: Mitochondrial Folies

29. Mitochondrial Follies: A Short Journey in Life and Energy
Anabela Marisa Azul, João Ramalho-Santos, Paulo Jorge Oliveira, Rui Tavares

Avainsanat: Biomedicine, Pharmacology/Toxicology, Medicinal Chemistry, Medical Biochemistry, Oxidative Stress