The Structural Basis of Arrestin Functions

Part I. Introduction

1. Arrestins: Discovery of the Family and Functional Role of Conformational Flexibility
Vsevolod V. Gurevich, Eugenia V. Gurevich

2. Overview of Arrestin Mediated Signaling with Receptors and Non-receptor Binding Partners
Ya Zhuo, Candice S. Klug

Part II. Localization of Functional Elements on Arrestins

3. Initial Crystallographic Studies of Visual Arrestin: Insights and Perspectives
Joel A. Hirsch

4. Structural Basis for β-Arrestins in GPCR Trafficking
Sungsoo M. Yoo, Dong Soo Kang, Jeffrey L. Benovic

5. Arrestin-3: The Structural Basis of Lower Receptor Selectivity
Benjamin W. Spiller, Xuanzhi Zhan, Vsevolod V. Gurevich

6. Phosphate Sensor and Construction of Phosphorylation-Independent Arrestins
Reuven Wiener, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Joel A. Hirsch

7. Comprehensive Analysis of the Role of Arrestin Residues in Receptor Binding
Raphael S. Haider, Aurélien Rizk, Gebhard F. X. Schertler, Martin K. Ostermaier

8. How Arrestin Recognizes and Binds Active GPCRs
Martha E. Sommer

9. Localization of Conformational Dynamics of Arrestins by HDX-MS
Ji Young Park, Hee Ryung Kim, Ka Young Chung

10. GPCR Footprint on Arrestins and Manipulation of Receptor Specificity
Sergey A. Vishnivetskiy, Wayne L. Hubbell, Candice S. Klug, Vsevolod V. Gurevich

Part III. Arrestin Flexibility and Activation

11. The Structure of the Polar Core Mutant R175E and Its Functional Implications
Renu Batra-Safferling, Joachim Granzin

12. Active Conformations of Arrestins: Expected and Unexpected Changes
Abhishek Bandyopadhyay, Ya Zhuo, Wayne L. Hubbell, Candice S. Klug, Vsevolod V. Gurevich, Oliver P. Ernst

13. The Arrestin-Receptor Complex: Exciting Answers and New Questions
Yanyong Kang, Karsten Melcher, Vsevolod V. Gurevich, H. Eric Xu

Part IV. Arrestin-Mediated Signaling and Biased Mutants

14. Scaffolding c-Jun N-Terminal Kinase Cascades: Mechanistic Insights from the Reconstituted Arrestin-JNK Cascades
Xuanzhi Zhan, Vsevolod V. Gurevich, Eugenia V. Gurevich

15. Arrestin-Dependent ERK Activation and Its Disruption
Louis M. Luttrell, Benjamin W. Spiller

16. The Functional Role of the Conformational Changes in Arrestin Upon Activation
Zhao Yang, Fan Yang, Anthony Nguen, Chuan Liu, Amy Lin, Thomas Joseph Cahill, Jin-Peng Sun

17. Is Signaling Specificity Encoded in Arrestin Conformation?
Carsten Hoffmann, Martin J. Lohse, Louis M. Luttrell

18. Monofunctional Elements of Multi-functional Proteins
Nicole A. Perry, Xuanzhi Zhan, T. M. Iverson, Eugenia V. Gurevich, Vsevolod V. Gurevich

19. Arrestins in Cell Death
Sandra Berndt, Vsevolod V. Gurevich, Eugenia V. Gurevich

Avainsanat: Life Sciences, Animal Biochemistry, Protein Science, Protein Structure