Patient-Derived Mouse Models of Cancer

1. In Memoriam: Jørgen Rygaard (1934–2016), Father of Patient-Derived Mouse Models of Cancer and Modern Cancer Research
Robert M. Hoffman

2. The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future
Robert M. Hoffman

3. Patient-Derived Xenograft Models for Human Cancer: The Freiburg Experience
Heinz-Herbert Fiebig

4. From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype
Bernard C. M. Sordat

5. The Effects of the Organ Microenvironment on Metastatic Cell Gene Signatures
Sun-Jin Kim, Ho Jeong Lee, Hyunkyung Yu, Sung II Choi, John Weinstein, Jing Wang, Yan Qi, Isaiah J. Fidler

6. Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice
Robert M. Hoffman

7. The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung, Breast, Ovary, and Mesothelioma
Robert M. Hoffman

8. Patient-Derived Xenograft Models of Prostate Cancer
R. B. Marques, C. M. A. Ridder, W. M. Weerden

9. Patient-Derived Mouse Models of Sarcoma
Tara A. Russell, Irmina A. Elliott, Arun S. Singh, Fritz C. Eilber

10. Cervical Cancer PDOX Models
Robert M. Hoffman, Yukihiko Hiroshima, Takashi Murakami, Takuya Murata

11. The Use of Pediatric Patient-Derived Xenografts for Identifying Novel Agents and Combinations
Raushan T. Kurmasheva, Peter J. Houghton

12. Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics
Marta Paez-Ribes, Raquel Munoz, Eric Guerin, Shan Man, Ping Xu, John Ebos, Christina Lee, Andrew Reynolds, Yuval Shaked, Robert S. Kerbel

13. Use of Patient-Derived Orthotopic Xenografts (PDOX) to Evaluate Transformative Cancer Therapeutics
Robert M. Hoffman

14. Fluorescent Protein-Expressing Transgenic Nude Mice as Hosts for Patient Tumors
Robert M. Hoffman

15. Fluorescence Imaging of Tumors in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models
Robert M. Hoffman, Atsushi Suetsugu, Tasuku Kiyuna, Shuya Yano, Michael Bouvet

16. The Use of Patient-Derived Orthotopic Xenograft (PDOX) Models to Develop Curative Fluorescence-Guided Surgery of Cancer
Robert M. Hoffman, Yukihiko Hiroshima, Shuya Yano, Cristina A. Metildi, Michael Bouvet

17. Molecular Characteristics of Patient-Derived Tumor Xenografts: Similarities to Patient Tumors and Relevance for Biomarker Discovery
Vincent Vuaroqueaux, Anne-Lise Peille, Bruno Zeitouni, Anne-Marie Eades-Perner, Heinz-Herbert Fiebig

18. Synergy of Patient-Derived Orthotopic Xenografts (PDOX) Models and Molecular Profiling for Optimal Therapy
Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Arun S. Singh, Fritz C. Eilber

19. 3D Cell Culture Models
David M. Evans, Beverly A. Teicher

20. Why Patient-Derived Mouse Models Need to Be Orthotopic
Robert M. Hoffman

21. Afterward: The Future of Patient-Derived Models of Cancer
Robert M. Hoffman

Avainsanat: Medicine & Public Health, Oncology, Cancer Research