Kala Azar in South Asia

Part I. Introduction Into Kala-Azar

1. Pathology and Mechanism of Disease in Kala-Azar
Shyamal Paul, Monira Pervin

2. Containing Post Kala-Azar Dermal Leishmaniasis (PKDL): Pre-requisite for Sustainable Elimination of Visceral Leishmaniasis (VL) from South Asia
Poonam Salotra, Himanshu Kaushal, V. Ramesh

3. Characteristics of Patients Visiting Suruya Kanta Kala-Azar Research Center in Mymensingh, Bangladesh; Data from a Patient Registry System
Masao Iwagami, Bumpei Tojo, Eisei Noiri

Part II. Therapeutic Strategy to Deal with Emergence of Drug Resistance

4. Epidemiology of Drug-Resistant Kala-Azar in India and Neighboring Countries
T. K. Jha

5. A Therapeutic Strategy for Treating Visceral Leishmaniasis in Regions with Drug Resistance
Shyam Sundar, Dipti Agarwal

6. Treatment of Post-kala-azar Dermal Leishmaniasis
V. Ramesh, Prashant Verma

7. Combination Therapy for Leishmaniases
Farrokh Modabber

8. Vaccine Development for Leishmaniasis
Yasuyuki Goto

9. Siccanin Is a Novel Selective Inhibitor of Trypanosomatid Complex II (Succinate-Ubiquinone Reductase) and a Potent Broad-Spectrum Anti-trypanosomatid Drug Candidate
Nozomu Nihashi, Daniel Ken Inaoka, Chiaki Tsuge, Emmanuel Oluwadare Balogun, Yasutaka Osada, Yasuyuki Goto, Yoshitsugu Matsumoto, Takeshi Nara, Tatsushi Mogi, Shigeharu Harada, Kita Kiyoshi

Part III. Diagnostic Strategy Enhancing Kala-Azar Elimination Program

10. Challenges in the Diagnosis of Visceral Leishmaniasis on the Indian Subcontinent
Suman Rijal, François Chappuis, Jorge Alvar, Marleen Boelaert

11. Changes of Leishmania Antigens in Kala-Azar Patients’ Urine After Treatment
Sharmina Deloer, Sohel Mohammad Samad, Hidekazu Takagi, Chatanun Eamudomkarn, Kazi M. Jamil, Eisei Noiri, Makoto Itoh

12. Potentiality of Urinary L-FABP Tests to Kala-Azar Disease Management
Eisei Noiri, Yoshifumi Hamasaki, Bumpei Tojo, Kazi M. Jamil, Kent Doi, Takeshi Sugaya

13. Antibody Capture Direct Agglutination Test (abcDAT) for Diagnosis of Visceral Leishmaniasis with Urine
Fumiaki Nagaoka, Hidekazu Takagi, Eisei Noiri, Makoto Itoh

14. Loop-Mediated Isothermal Amplification (LAMP
): Molecular Diagnosis for the Field Survey of Visceral Leishmaniasis
Hidekazu Takagi, Makoto Itoh, Eisei Noiri

15. Applicability of Multiplex Real-Time PCR to Visceral Leishmaniasis
Yoshifumi Hamasaki, Hirofumi Aruga, Chizu Sanjoba, Hidekazu Takagi, Shyamal Paul, Yoshitsugu Matsumoto, Eisei Noiri

Part IV. Pathogenesis of Kala-Azar and PKDL

16. Immunoglobulins in the Pathophysiology of Visceral Leishmaniasis
Satoko Omachi, Yoshitsugu Matsumoto, Yasuyuki Goto

Part V. Knowledge and Practice for Vector Control in Kala-Azar

17. GeographicalDistribution and Ecological Aspect of Sand Fly Species in Bangladesh
Yusuf Özbel, Chizu Sanjoba, Yoshitsugu Matsumoto

18. The Efficacy of Long Lasting Insecticidal Nets for Leishmaniasis in Asia
Chizu Sanjoba, Yusuf Özbel, Yoshitsugu Matsumoto

Part VI. New Challenges in Kala-Azar Elimination Programme

19. Environmental Change and Kala-Azar with Particular Reference to Bangladesh
Ashraf Dewan, Masahiro Hashizume, Md. Masudur Rahman, Abu Yousuf Md. Abdullah, Robert J. Corner, Md. Rakibul Islam Shogib, Md. Faruk Hossain

20. Drug Safety Monitoring for Liposomal Amphotericin B
Eisei Noiri, Kosuke Minami

21. High Resolution Mapping of Kala-Azar Hot Spots Using GPS Logger and Urinary Antibody Measurements
Bumpei Tojo, Makoto Itoh, Mohammad Sohel Samad, Emi Ogasawara, Dinesh Mondal, Rashidul Haque, Eisei Noiri

22. Geography and Reality of Kala-Azar Endemic in Bangladesh, Analysis Using GIS and Urine-Based Mass Screening
Bumpei Tojo, Makoto Itoh, Shyamal Kumar Paul, Mohammad Sohel Samad, Emi Ogasawara, Fumiaki Nagaoka, Dinesh Mondal, Rashidul Haque, Eisei Noiri

23. Animal Models of Visceral Leishmaniasis and Applicability to Disease Control
Yasutaka Osada, Satoko Omachi, Chizu Sanjoba, Yoshitsugu Matsumoto

24. Pharmacovigilance on Therapeutic Protocols for Visceral Leishmaniasis
Eisei Noiri, Bumpei Tojo, Yoshifumi Hamasaki, Masao Iwagami, Takeshi Sugaya, Michiyo Harada, Progga Nath, Ariful Basher, Dinesh Mondal, Rashidul Haque, Fasifur Rahman, Shyamal Paul

Avainsanat: Biomedicine, Parasitology, Drug Resistance, Veterinary Medicine/Veterinary Science, Laboratory Medicine, Nephrology