Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins

1. Chemical Assembly of Antibody-Drug Conjugates
Alex R. Nanna, William R. Roush, Christoph Rader

2. Preclinical Evaluation of ADCs Delivering Highly Potent Pyrrolobenzodiazepine (PBD) Dimers
John A. Hartley

3. Stable and Homogeneous Drug Conjugation by Sequential Bis-Alkylation at Disulphide Bonds Using Bis-Sulphone Reagents
Martin Pabst, Matthew Bird, Mark Frigerio, Antony Godwin

4. Calicheamicin Antibody-Drug Conjugates for Liquid and Solid Tumor Indications
Hans-Peter Gerber, Marc Damelin, Puja Sapra

5. Enzyme-Based Strategies to Generate Site-Specifically Conjugated Antibody Drug Conjugates
Roger R. Beerli, Ulf Grawunder

6. Substance P–Saporin for the Treatment of Intractable Pain
Hugh Nymeyer, Douglas A. Lappi, Denise Higgins, Carl E. Noe, Arthur E. Frankel

7. Recombinant Immunotoxins for Chronic Inflammatory Disease
Theo Thepen, Stefan Barth

8. BL22: A Milestone in Targeting CD22
Robert J. Kreitman, David J. P. FitzGerald, Ira Pastan

Avainsanat: Biomedicine, Pharmacology/Toxicology, Antibodies, Pharmacotherapy, Cancer Research, Oncology