The Hypothalamic-Pituitary-Adrenal Axis in Health and Disease

Part I. Hypothalamic-Pituitary-Adrenal Axis Regulation of the Body, Brain, and Inflammation

1. Glucocorticoid Regulation of Body Composition and Metabolism
Alexandria Atuahene Opata, Khadeen C. Cheesman, Eliza B. Geer

2. Glucocorticoid Regulation of Neurocognitive and Neuropsychiatric Function
Alberto M. Pereira, Onno C. Meijer

3. Glucocorticoids: Inflammation and Immunity
Maria G. Petrillo, Carl D. Bortner, John A. Cidlowski

Part II. Cushing’s Syndrome

4. Molecular Pathogenesis of Primary Adrenal Cushing’s Syndrome
Nada Ghorayeb, Isabelle Bourdeau, André Lacroix

5. Pathogenesis and Treatment of Aggressive Corticotroph Pituitary Tumors
Yang Shen, Anthony P. Heaney

6. Neoplastic/Pathological and Nonneoplastic/Physiological Hypercortisolism: Cushing Versus Pseudo-Cushing Syndromes
James W. Findling, Hershel Raff

7. Imaging Strategies for Localization of ACTH-Secreting Tumors
Lynnette K. Nieman, Ahmed M. Gharib

8. Surgical Treatment of Cushing’s Disease
Hekmat Zarzour, Margaret Pain, Joshua Bederson, Kalmon D. Post

9. Medical Therapies in Cushing’s Syndrome
Nicholas A. Tritos, Beverly M. K. Biller

10. Mild Adrenal Cortisol Excess
Adina F. Turcu, Richard J. Auchus

11. Long-Term Effects of Prior Cushing’s Syndrome
Anna Aulinas, Elena Valassi, Eugenia Resmini, Alicia Santos, Iris Crespo, María-José Barahona, Susan M. Webb

12. Cushing’s Disease, Refining the Definition of Remission and Recurrence
Jeremy N. Ciporen, Justin S. Cetas, Shirley McCartney, Maria Fleseriu

Part III. Beyond Cushing’s: Glucocorticoid Sensitivity, Regulation, and the Metabolic Syndrome

13. Primary Generalized Glucocorticoid Resistance or Chrousos Syndrome: Allostasis Through a Mutated Glucocorticoid Receptor
Nicolas C. Nicolaides, Agaristi Lamprokostopoulou, Amalia Sertedaki, George P. Chrousos, Evangelia Charmandari

14. Cortisol Metabolism as a Regulator of the Tissue-Specific Glucocorticoid Action
Emilia Sbardella, Jeremy W. Tomlinson

15. Obesity and Metabolic Syndrome: A Phenotype of Mild Long-Term Hypercortisolism?
Vincent L. Wester, Elisabeth F. C. Rossum

Avainsanat: Medicine & Public Health, Endocrinology, Systems Biology