Neuroprotective Therapy for Stroke and Ischemic Disease

Part I. Stroke Neuroprotection: The History and Learning Experience

1. Reflections on Neuroprotection Research and the Path Toward Clinical Success
Paul A. Lapchak, Paul D. Boitano

2. Systematic Review and Meta-analysis: Important Tools in Understanding Drug Development for Stroke
Sarah K. McCann, Emily S. Sena, Gillian L. Currie, Malcolm R. Macleod, David W. Howells

3. Neuroprotection Is Technology, Not Science
Donald J. DeGracia, Doaa Taha, Fika Tri Anggraini, Zhifeng Huang

4. History of Experimental Stroke Research
Victoria E. O’Collins

5. History of Neuroprotection: Trials and Tribulations
Ali Razmara, Steven C. Cramer

Part II. Novel Neuroprotection Mechanisms and Targets

6. Targeting PSD-95 as a Novel Approach in the Treatment of Stroke
Linda M. Haugaard-Kedström, Eduardo F. A. Fernandes, Kristian Strømgaard

7. ATP-Sensitive Potassium Channels (KATP) Play a Role in Hypoxic Preconditioning Against Neonatal Hypoxic-Ischemic Brain Injury
Zhong-Ping Feng, Hong-Shuo Sun

8. Targeting Oxidative Stress in Stroke
Anders Bach

9. Nitrones, Old Fellows for New Therapies in Ischemic Stroke
Alejandro Escobar-Peso, Mourad Chioua, Valerio Frezza, Emma Martínez-Alonso, José Marco-Contelles, Alberto Alcázar

10. Neuroprotective Strategies via Modulation of Innate Immune Receptors
George Trendelenburg

11. Harnessing the Power of the Human Immune System via Multi-omic Immune Profiling in Stroke Treatment and Recovery
Taura L. Barr, V. Gionis, R. Giersch

12. Polarization of Microglia/Macrophages in Brain Ischaemia: Relevance for Stroke Therapy
Diana Amantea, Rosaria Greco, Cristina Tassorelli, Giacinto Bagetta

13. Endoplasmic Reticulum Stress: An Opportunity for Neuroprotective Strategies After Stroke
Morgane Louessard, Eloise Lemarchand, Carine Ali, Denis Vivien, Benoit Denis Roussel

14. Effects of Neuroprotectants Before and After Stroke: Statins and Anti-hypertensives
Roberto Federico Villa, Federica Ferrari, Antonio Moretti

15. Toward Effective Combination Therapy and Pleiotropic Drugs
Sergio Amaro, Xabier Urra, Ángel Chamorro

16. TRPM7 Channels as Potential Therapeutic Targets for Stroke
Hong-Shuo Sun, Zhong-Ping Feng

17. Cholinergic Protection in Ischemic Brain Injury
Victor V. Uteshev

18. Remote Ischemic Conditioning: A Highly Translatable Therapy for Acute Stroke
Chizoba J. Ezepue, David C. Hess

19. Hypothermia for Acute Ischemic Stroke
Roy Poblete, Gene Sung

20. Modern Endovascular Treatment of Ischemic Disease
Steven L. Gogela, Todd A. Abruzzo, Mario Zuccarello

21. Cerebral Microbleeds and Thrombolysis for Acute Ischemic Stroke
JungSeok Lee, Mark Fisher

22. Targeting Pericytes and the Microcirculation for Ischemic Stroke Therapy
Ain A. Neuhaus, Brad A. Sutherland, Alastair M. Buchan

Part III. Thrombolysis and Embolectomy

23. Thrombolytic and Endovascular Therapies for Acute Ischemic Stroke
Hormozd Bozorgchami, Helmi L. Lutsep

24. Sonothrombolysis for Acute Ischemic Stroke: A Critical Appraisal
Georgios Tsivgoulis, Apostolos Safouris, Andrei V. Alexandrov

25. Combination Therapy with Thrombolysis
Burak Yulug, Wolf-Rüdiger Schäbitz

26. Oxygen Carriers: Are They Enough for Cellular Support?
Jennifer L. H. Johnson

27. A New Paradigm in Protecting Ischemic Brain: Preserving the Neurovascular Unit Before Reperfusion
Natacha Moan, Philberta Y. Leung, Natalia Rost, Jonathan A. Winger, Ana Krtolica, Stephen P. Cary

Part IV. Stroke Models and Clinical Trial Considerations

28. The Right Rodent for the Job: Infarct Variability Between Strains and Its Impact on Logistics of Experimental Animal Studies
Sarah Rewell, David W. Howells

29. Rabbit Spinal Cord Ischemia Model for the Development of Neuroprotective Treatments
Daisy Chou, Anja Muehle, Paul A. Lapchak, Ali Khoynezhad

30. Stroke Sex Differences: From Basic Research to Clinical Trials
Claire L. Gibson, Philip M. W. Bath, Raeed Altaee

31. Unpuzzling the Comorbid Type 2 Diabetes and Hypertension-Related Cognitive Dysfunction and Stroke
I. Sebastião, E. Candeias, M. S. Santos, C. R. Oliveira, Paula I. Moreira, Ana I. Duarte

32. Sex-Specific Factors in Stroke
Anjali Chauhan, Hope Moser, Louise D. McCullough

33. Current Imaging Strategies for Patient Selection in Acute Ischemic Stroke Trials
Jenny P. Tsai, Gregory W. Albers

Avainsanat: Biomedicine, Neurosciences, Cardiology