Small Animal Imaging

Part I. Role of Small Animal Imaging

1. Noninvasive Imaging for Supporting Basic Research
Pat Zanzonico

2. Non-invasive Imaging in the Pharmaceutical Industry
Sally-Ann Emmas, Paul D. Hockings, John C. Waterton

3. Designing a Small Animal Imaging Center
David Stout

4. Noninvasive Small Rodent Imaging: Significance for the 3R Principles
Nicolau Beckmann, Birgit Ledermann

Part II. Study Planning and Animal Preparation

5. Institutional Preconditions for Small Animal Imaging
René H. Tolba

6. Statistical Considerations for Animal Imaging Studies
Hannes-Friedrich Ulbrich

7. Anesthesia and Analgesia in Laboratory Animals
Marc Hein, Anna B. Roehl, René H. Tolba

8. Drug Administration
Peter Hauff, Klaus Nebendahl

Part III. Imaging Modalities and Probes

9. How to Choose the Right Imaging Modality
Fabian Kiessling, Bernd Pichler, Peter Hauff

10. How to Identify Suitable Molecular Imaging Biomarkers
Norman Koglin, Andre Mueller, Andrew W. Stephens, Ludger M. Dinkelborg

11. Concepts in Diagnostic Probe Design
Igor Jacobs, Gustav J. Strijkers, Henk M. Keizer, Henk M. Janssen, Hisataka Kobayashi, Klaas Nicolay

12. X-Ray and X-Ray-CT
Robert Brauweiler, Klaus Engelke, Martin Hupfer, Willi A. Kalender, Marek Karolczak, Hubertus Pietsch

13. MRI
Aileen Schroeter, Markus Rudin, Eliana Gianolio, Alessandra Viale, Daniela Delli Castelli, Silvio Aime, Jan-Bernd Hövener, Jessica A. M. Bastiaansen, Arnaud Comment, Stephan Düwel, Jan H. Ardenkjaer-Larsen, Markus Becker

14. Ultrasound
Stuart Foster, J. M. Hyvelin, Minalini Lakshman, Andrew Needles, I. Tardy, François Tranquart

15. PET and SPECT
Clemens Decristoforo, Uwe Haberkorn, Roland Haubner, Walter Mier, Sibylle I. Ziegler

16. Optical Imaging
Frauke Alves, Julia Bode, Peter Cimalla, Ingrid Hilger, Martin Hofmann, Volker Jaedicke, Edmund Koch, Kai Licha, Timo Rademakers, Daniel Razansky, Marc A. M. J. Zandvoort

17. Multimodal Imaging and Image Fusion
Hans F. Wehrl, Mario Amend, André Thielcke

Part IV. Ex Vivo Validation Methods

18. In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting
David Stout, Cinthia Pastuskovas

Part V. Data Postprocessing

19. Qualitative and Quantitative Data Analysis
Felix Gremse

20. Guidelines for Nuclear Image Analysis
Martin S. Judenhofer, Stefan Wiehr, Damaris Kukuk, Kristina Fischer, Bernd J. Pichler

21. Kinetic Modeling
J. Hoff

22. Data Management in Small Animal Imaging: Conceptual and Technical Considerations
J. Maus, F. Hofheinz

Part VI. Special Applications

23. Cell Tracking and Transplant Imaging
Laura C. Rose, Jeff W. M. Bulte

24. Beta Cell Imaging as Part of “Imaging on Metabolic Diseases”
M. Brom, W. A. Eter, I. Kroon, S. M. A. Willekens, A. Eek, M. Boss, M. Buitinga, M. Gotthardt

25. In Vivo Preclinical Imaging of Developmental Biology
Katrien Vandoorne, Tal Raz, Stav Sapoznik, Inbal E. Biton, Joel R. Garbow, Michal Neeman

26. Imaging in Gynecology Research
Matthias W. Laschke, Michael D. Menger

27. Imaging in Cardiovascular Research
Michael Schäfers, Michael Kuhlmann, Lars Stegger, Klaus Schäfers, Sven Hermann

28. Imaging in Neurooncology
Yannic Waerzeggers, Bastian Zinnhardt, Alexandra Winkeler, Parisa Monfared, Sonja Schelhaas, Thomas Viel, Andreas H. Jacobs

29. Imaging in Neurology Research II: Exploring Plasticity and Cognitive Networks by In Vivo MRI
J. Hamaide, L. Ruijssevelt, F. Kara, G. Groof, A. Linden

30. Imaging in Neurology Research III: Neurodegenerative Diseases
Heike Endepols, Bernd Neumaier

31. When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals
Xin Yu

32. Imaging in Oncology Research
Wolfgang A. Weber, Fabian Kiessling

33. PET Imaging in Immunology
Melissa N. McCracken, Owen N. Witte

34. Molecular Imaging of Infectious Diseases
Anna-Maria Rolle, Stefan Wiehr

Avainsanat: Medicine & Public Health, Imaging / Radiology, Laboratory Medicine, Pharmacology/Toxicology