Efflux-Mediated Antimicrobial Resistance in Bacteria

Part I. Bacterial Drug Efflux Pumps: Structures and Transport Mechanisms

1. Structures and Transport Mechanisms of RND Efflux Pumps
Satoshi Murakami

2. Structural and Functional Landscape of MFS and MATE Efflux Pumps
Asha V. Nair, Kenneth W. Lee, Hendrik W. Veen

3. Small Multidrug Resistance Efflux Pumps
Denice C. Bay, Raymond J. Turner

4. Structures and Transport Mechanisms of the ABC Efflux Pumps
Cédric Orelle, Jean-Michel Jault

5. Multidrug Efflux in the Context of Two-Membrane Cell Envelopes
Helen I. Zgurskaya, Vassiliy N. Bavro, Jon W. Weeks, Ganesh Krishnamoorthy

Part II. Bacterial Drug Efflux Pumps in Antimicrobial Resistance: Substrates, Regulation and Clinical Significance

6. Antimicrobial Resistance in Bacteria: An Overview of Mechanisms and Role of Drug Efflux Pumps
Xian-Zhi Li

7. Antimicrobial Drug Efflux Pumps in Staphylococcus aureus

Sylvia A. Sapula, Melissa H. Brown

8. Antimicrobial Drug Efflux Pumps in Other Gram-Positive Bacteria
Natalya Baranova, Christopher A. Elkins

9. Antimicrobial Drug Efflux Pumps in Escherichia coli

Xian-Zhi Li, Hiroshi Nikaido

10. Antimicrobial Drug Efflux Pumps in Salmonella

Kunihiko Nishino

11. Antimicrobial Drug Efflux Pumps in Enterobacter and Klebsiella

Anne Davin-Regli, Muriel Masi, Suzanne Bialek, Marie-Hélène Nicolas-Chanoine, Jean-Marie Pagès

12. Antimicrobial Resistance and Drug Efflux Pumps in Vibrio and Legionella

Yuji Morita, Xian-Zhi Li

13. Antimicrobial Resistance and Drug Efflux Pumps in Acinetobacter

Bao-Dong Ling, Li Zhang, Xian-Zhi Li

14. Antimicrobial Drug Efflux Pumps in Pseudomonas aeruginosa

Xian-Zhi Li, Patrick Plésiat

15. Antimicrobial Drug Efflux Pumps in Stenotrophomonas maltophilia

María B. Sánchez, Guillermo García-León, Alvaro Hernández, José L. Martínez

16. Antimicrobial Drug Efflux Pumps in Burkholderia

Viola Camilla Scoffone, Tom Coenye, Giovanna Riccardi, Silvia Buroni

17. Efflux Pumps in Neisseria gonorrhoeae: Contributions to Antimicrobial Resistance and Virulence
William M. Shafer, Edward W. Yu, Corinne Rouquette-Loughlin, Daniel Golparian, Ann E. Jerse, Magnus Unemo

18. Efflux Pumps in Campylobacter: Key Players for Antimicrobial Resistance and Environmental Adaption
Lei Dai, Zhangqi Shen, Edward W. Yu, Qijing Zhang

19. Antimicrobial Resistance and Drug Efflux Pumps in Helicobacter

Jennifer Li, Xian-Zhi Li

20. Antimicrobial Resistance and Drug Efflux Pumps in Bacteroides

Julio Aires

21. Efflux Pumps in Mycobacteria: Antimicrobial Resistance, Physiological Functions, and Role in Pathogenicity
Pedro Eduardo Almeida Silva, Diana Machado, Daniela Ramos, Isabel Couto, Andrea Groll, Miguel Viveiros

22. Antimicrobial Drug Efflux Genes and Pumps in Bacteria of Animal and Environmental Origin
Lateef Adewoye, Edward Topp, Xian-Zhi Li

23. Role of Plasmid-Encoded Drug Efflux Pumps in Antimicrobial Resistance
Xian-Zhi Li, Manisha Mehrotra

24. Influence of Regulatory RNAs on Antimicrobial Resistance and Efflux Mechanisms
Xu Jia, Bao-Dong Ling, Xian-Zhi Li

Part III. Role of Drug Efflux Pumps Beyond Antimicrobial Resistance: Natural Functions

25. The Relationship Between Bacterial Multidrug Efflux Pumps and Biofilm Formation
Alexander Fahmy, Ananth Srinivasan, Mark A. Webber

26. Antimicrobial Drug Efflux Systems as Components of Bacterial Stress Responses
Keith Poole, Michael Fruci

27. Involvement of Antimicrobial Drug Efflux Systems in Bacterial Fitness and Virulence
Natalya Baranova

Part IV. Antimicrobial Development and Efflux Pump Inhibitors

28. Impact of Antimicrobial Drug Efflux Pumps on Antimicrobial Discovery and Development
Xian-Zhi Li

29. Antimicrobial Drug Efflux Pump Inhibitors
Jürgen A. Bohnert, Winfried V. Kern

30. Multidrug Efflux Pumps and Their Inhibitors Characterized by Computational Modeling
Venkata Krishnan Ramaswamy, Pierpaolo Cacciotto, Giuliano Malloci, Paolo Ruggerone, Attilio V. Vargiu

Avainsanat: Biomedicine, Drug Resistance, Infectious Diseases