The Genetics of Type 2 Diabetes and Related Traits

Part I. Genetic Discovery

1. Historical Overview of Gene Discovery Methodologies in Type 2 Diabetes
Amélie Bonnefond, Alan R. Shuldiner, Philippe Froguel

2. Genome-Wide Association Studies of Type 2 Diabetes
Rob Sladek, Inga Prokopenko

3. Genome-Wide Association Studies of Quantitative Glycaemic Traits
Inês Barroso, Robert Scott

4. Genome-Wide Association Studies (GWAS) of Adiposity
Erik Ingelsson, Tuomas O. Kilpeläinen

5. Sequencing Approaches to Type 2 Diabetes
Jeffrey W. Kleinberger, Toni I. Pollin

6. Fine-Mapping of Type 2 Diabetes Loci
Laura J. Scott, Karen L. Mohlke

7. Genetics of Diabetic Micro- and Macrovascular Complications
Niina Sandholm, Per-Henrik Groop, Alessandro Doria

Part II. Interpretation and Data Integration

8. Transferability Across Ethnic Groups
Richa Saxena, Nicholette D. Palmer

9. Physiology Insights
Richard M. Watanabe, Torben Hansen

10. Insights from Monogenic Diabetes
Tormund Salvesen Njølstad, Sian Ellard, Pål Rasmus Njølstad

11. Epigenetics in Type 2 Diabetes
Charlotte Ling, Lorenzo Pasquali

12. Gene-Environment Interaction: Methods and Examples in Type 2 Diabetes and Obesity
Alisa K. Manning

13. The Gut Microbiota in Type 2 Diabetes
Trine Nielsen, Kristine H. Allin, Oluf Pedersen

Part III. From Association to Function

14. Transcription Factor 7-Like 2 (TCF7L2)
Struan F. A. Grant, Leif Groop

15.
GCKR: How Genetic Variation Across the Allelic Spectrum Influences Protein Function and Metabolic Traits in Humans
Marju Orho-Melander, Anna L. Gloyn

16. Genetic and Functional Studies Implicate G6PC2 in the Regulation of Fasting Blood Glucose
Nabila Bouatia-Naji, Richard M. O’Brien

17. From Association to Function: KCNJ11 and ABCC8

Michael N. Weedon, Peter Light

18.
SLC30A8: A Complex Road from Association to Function
Jason Flannick, William L. Lowe

19. From Association to Function: MTNR1B

Amélie Bonnefond, Valeriya Lyssenko

Part IV. Clinical Translation

20. Type 2 Diabetes Prediction
Shuai Wang, Frank B. Hu, Josée Dupuis

21. The Value of Genetic Variation in the Prediction of Obesity
Ruth J. F. Loos, A. Cecile J. W. Janssens

22. Pharmacogenetics of Metformin
Sook Wah Yee, Kaixin Zhou, Kathleen M. Giacomini

23. Pharmacogenetics of Sulfonylureas
Peter Kovacs, Ewan Pearson

24. Causal Inference in Medicine via Mendelian Randomization
Timothy M. Frayling, Benjamin F. Voight

25. Diabetes Prevention
Marie-France Hivert, William C. Knowler

26. Nutrigenetics of Type 2 Diabetes
Lu Qi, Paul W. Franks

27. Epilogue: What the Future Holds: Genomic Medicine at the Heart of Diabetes Management
Mark I. McCarthy, David Altshuler, Michael Boehnke

Avainsanat: Biomedicine, Human Genetics, Diabetes, Human Physiology