GABA and Sleep

Part I. Basic Physiology and Pharmacology

1. Physiology and Pharmacology of the GABA System: Focus on GABA Receptors
Hanns Möhler

2. Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy
John R. Atack

3. Distribution of GABAA Receptor Subunits in the Human Brain
H. J Waldvogel, K Baer, R. L. M. Faull

4. Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics
David J. Greenblatt

Part II. Sleep Science and Circuitry

5. Sleep and Its Modulation by Substances That Affect GABAA Receptor Function
Axel Steiger

6. Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System
J. Josh Lawrence

7. Function of GABAB and ρ-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes
Claude Gottesmann

8. Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness
Jaime M. Monti

9. GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation
Dinesh Pal, Birendra Nath Mallick

10. Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT–PPT) in the Promotion of REM Sleep
Pablo Torterolo, Giancarlo Vanini

11. GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site – in the Modulation of Sleep–Wake States
Fernando Reinoso-Suárez, Carmen Roza, Margarita L Rodrigo-Angulo, Isabel Andrés, Ángel Núñez, Miguel Garzón

12. The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep
Gerald A Marks, Christopher M Sinton

13. Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms
Daniel P. Cardinali, S. R. Pandi-Perumal, Lennard P. Niles, Gregory M. Brown

14. GABA Involvement in the Circadian Regulation of Sleep
J. Christopher Ehlen, Daniel L. Hummer, Ketema N. Paul, H. Elliott Albers

Part III. Hypnotics

15. Pathophysiology of Sleep Disorders
Thomas C. Wetter, Pierre A. Beitinger, Marie E. Beitinger, Bastian Wollweber

16. Insomnia: Differential Diagnosis and Current Treatment Approach
J. F Pagel, Gerald Kram

17. Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients
Luc Staner, Françoise Cornette, Sarah Otmani, Jean -François Nedelec, Philippe Danjou

18. Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia
Jadwiga S. Najib

19. Indiplon
David N. Neubauer

20. Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia
Joseph Barbera, Colin Shapiro

Avainsanat: Biomedicine, Human Physiology