Protein Kinase C in Cancer Signaling and Therapy

1. Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective
Alex Toker

2. Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids
Alexandra C. Newton

3. Phorbol Esters and Diacylglycerol: The PKC Activators
Peter M. Blumberg, Noemi Kedei, Nancy E. Lewin, Dazhi Yang, Juan Tao, Andrea Telek, Tamas Geczy

4. Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals
Isabel Mérida, Silvia Carrasco, Antonia Avila-Flores

5. Regulation of PKC by Protein–Protein Interactions in Cancer
Jeewon Kim, Daria Mochly-Rosen

6. Introduction: PKC Isozymes in the Control of Cell Function
Gry Kalstad Lønne, Christer Larsson

7. Regulation and Function of Protein Kinase D Signaling
Enrique Rozengurt

8. PKC and Control of the Cell Cycle
Jennifer D. Black

9. PKC and the Control of Apoptosis
Mary E. Reyland, Andrew P. Bradford

10. Atypical PKCs, NF-κB, and Inflammation
Maria T. Diaz-Meco, Jorge Moscat

11. Introduction: PKC and Cancer
Marcelo G. Kazanietz

12. Protein Kinase C, p53, and DNA Damage
Kiyotsugu Yoshida

13. PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways
Natalia A. Riobo

14. PKC–PKD Interplay in Cancer
Q. Jane Wang

15. Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer
Ajit K. Verma

16. PKC Isozymes and Skin Cancer
Mitchell F. Denning

17. PKC and Breast Cancer
Sofia D. Merajver, Devin T. Rosenthal, Lauren Wassenhove

18. PKC and Prostate Cancer
Jeewon Kim, Marcelo G. Kazanietz

19. Protein Kinase C and Lung Cancer
Lei Xiao

20. Introduction
Patricia S. Lorenzo

21. PKC and Resistance to Chemotherapeutic Agents
Alakananda Basu

22. PKCδ as a Target for Chemotherapeutic Drugs
Chaya Brodie, Stephanie L. Lomonaco

23. Atypical PKCs as Targets for Cancer Therapy
Verline Justilien, Alan P. Fields

Avainsanat: Biomedicine, Cancer Research, Pharmacology/Toxicology