Functional Selectivity of G Protein-Coupled Receptor Ligands

2. Historical Overview of the Concept of Functional Selectivity
Bryan L. Roth

3. Functional Selectivity: Theoretical Considerations and Future Directions
Terry Kenakin

4. Agonist-Selective Coupling of G Protein-Coupled Receptors
Barbara Bosier, Emmanuel Hermans

5. Ligand-Selective Receptor Desensitization and Endocytosis
Jennifer L. Whistler

6. Selectivity for G Protein or Arrestin-Mediated Signaling
Laura M. Bohn

7. In Vivo Evidence for and Consequences of Functional Selectivity
Kim A. Neve, Marc G. Caron, Jean-Martin Beaulieu

8. Functional Selectivity at Adrenergic Receptors
Richard R. Neubig

9. Signaling Diversity Mediated by Muscarinic Acetylcholine Receptor Subtypes and Evidence for Functional Selectivity
R.A. John Challiss, Rachel L. Thomas

10. Functional Selectivity at Serotonin Receptors
Kelly A. Berg, William P. Clarke

11. Functional Selectivity at Dopamine Receptors
Richard B. Mailman, Yan-Min Wang, Andrew Kant, Justin Brown

12. Functional Selectivity at Receptors for Cannabinoids and Other Lipids
Allyn C. Howlett

13. Functional Selectivity at Opioid Receptors
Graciela Piñeyro

14. Functional Selectivity at Non-Opioid Peptide Receptors
Anushree Bhatnagar, Sadashiva Karnik

Avainsanat: Biomedicine, Human Physiology, Neurology, Neurobiology, Pharmacology/Toxicology, Neurosciences