Jakowlew, Sonia B.
Transforming Growth Factor-β in Cancer Therapy, Volume I
I. Basic Concepts of TGF-β Signaling in Normal Physiology and Cancer Pathobiology
1. Component Hardware for Transforming Growth Factor-β Signal Transduction: TGF-β Ligands, TGF-β Receptors, and Smads
Sonia B. Jakowlew
2. TGF-β Signaling in Homeostasis and Cancer
Joan Seoane
3. TGF-β Availability: Latent TGF-β and Latent TGF-β Binding Proteins
Vesna Todorovic, Daniel B. Rifkin
4. Biological Functions of Latent TGF-β-Binding Proteins and Activation of TGF-β
Marko Hyytiäinen, Katri Koli, Jorma Keski-Oja
5. Regulators of Smad2/3 Transcription and Phosphorylation
Azeddine Atfi, Marie-Francoise Bourgeade
6. Interaction of Smad4 and Embryonic Liver Fodrin-β-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression
Sang Soo Kim, Charles Shuman, Lopa Mishra
7. Regulation of Smad Activity by Phosphorylation
Fang Liu
8. Nuclear Targeting of TGF-β-Activated Smads in Normal and Tumor Biology
Lan Xu
9. Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival
Erwan Scolan, Kunxin Luo
10. Transforming Growth Factor-β in Cancer Therapy: Smurfs in TGF-β Signaling and Regulation of Bone Homeostasis and Cancer
Ying E. Zhang, Motozo Yamashita
11. Involvement of km23 Dynein Light Chains in TGF β Signaling
Qunyan Jin, Guofeng Gao, Kathleen M. Mulder
12. TGF-β Signaling in Fibroblastic Cells and Oncogenesis
Neil A. Bhowmick
13. Mechanisms of TGF-β-Induced Apoptosis in Cancer Cells
Tae-Aug Kim, Seong-Jin Kim
14. Mechanisms of Cell Cycle Regulation by TGF-β Disabled in Cancer
Leslie I. Gold, Jon Lecanda
15. Transforming Growth Factor-β in Cancer Therapy
Arja Band, Marikki Laiho
16. TGF-β and Smad Signaling in Transcriptome Reprogramming During EMT
Sylvie Thuault, Ulrich Valcourt, Marcin Kowanetz, Aristidis Moustakas
17. Functional Interactions Between MMPs and TGF-β in Normal and Tumor Tissue
Christina H. Stuelten, Anita B. Roberts, William G. Stetler-Stevenson
18. Cooperation Between TGF-β and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function
Irwin M. Liu, Stephen H. Schilling, Xiao-Fan Wang
19. Interaction of Oncogenic Ras and TGFβ1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model
Adam Glick, Dong-Soon Bae, Xin Liu, Kinnimulki Vijayachandra
II. TGF-β Superfamily Members in Normal and Tumor Biology
20. Proteomics Analysis of TGFβ Superfamily Members
Serhiy Souchelnytskyi
21. Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers
David T. MacLaughlin, Patricia K. Donahoe
22. Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression
Tetsu Hayashida, Vandana Gupta, Sam Thiagalingam, Shyamala Maheswaran
23. Bone Morphogenic Proteins and Angiogenesis in Developing Tumors
George Berberian, Deepak Malhotra, John E. Langenfeld
24. Histone Methyltransferase and Smad Interactions in BMP Signaling
Jennifer E. Leader, M. Pilar Frontelo, Robert J. Lechleider
25. Endoglin (CD105): A Strong Candidate for Immunologic Targeting of Tumor Neovasculature in Human Malignancies
Ester Fonsatti, Michele Maio
26. Activins and Inhibins in Cancer Progression
Gail P. Risbridger, Christopher Butler
27. Bone Morphogenetic Proteins/Growth Differentiation Factors and Smad Activation in Ovarian Granulosa Cells and Carcinoma
Sabine Mazerbourg
28. Regulation of the Transforming Growth Factor-β Superfamily by Betaglycan
Fernando López-Casillas, M. Magdalena Vilchis-Landeros, José Esparza-López, M. Verónica Ponce-Castañeda, N. Gabriela Velasco-Loyden, Patricia Juárez, Jose Luis Montiel, Valentín Mendoza
29. Uterine Sensitization Associated Gene-1: A Bone Morphogenetic Protein Antagonist with a Role in Kidney
Motoko Yanagita
30. Role of Betaig-h3 Gene in Carcinogenesis
Yongliang Zhao, Tom K. Hei
31. Activins and the Liver
Michael Grusch, Chantal Rodgarkia-Dara, Wilfried Bursch, Rolf Schulte-Hermann
32. Myostatin Signaling in Normal and Tumor Cells
Xiangyang Zhu, Li-fang Liang, Ronald L. Stotish
III. TGF-β in Inflammation and Fibrosis
33. Triterpenoids, Vitamin D, and TGF-β/Smad Signaling in Inflammation and Cancer
Nanjoo Suh
34. Thrombospondin-Dependent Activation of Latent TGF-β in Fibrosis and Disease
Joanne E. Murphy-Ullrich
35. TGF-β in Pulmonary Fibrosis
Masahito Ebina
36. The Role of TGF-β in Bleomycin Induced Pulmonary Fibrosis
Nasreen Khalil, Robert O’Connor
37. Smads in the Fibrotic Response: Findings in the Smad3 Knockout Mouse
Kathleen C. Flanders
38. TGF-β Signaling in Renal Fibrosis and Inflammation: Gene Therapy Using Ultrasound-Microbubble-Mediated Inducible Smad7
Hui Y. Lan
39. Transforming Growth Factor-β Peptide Signaling in Pulmonary Development, Bronchopulmonary Dysplasia, Fibrosis, and Emphysema
David Warburton, Wei Shi, Martin Kolb, Jack Gauldie
40. The Role of TGF-β in Radiation and Chemotherapy Induced Pulmonary Fibrosis: Inhibition of TGF-β as a Novel Therapeutic Strategy
Patricia J. Sime, R. Matthew Kottmann, Heather F. Lakatos, Thomas H. Thatcher
41. Negative Regulation of the TGF-β Family Signal Pathway by Inhibitory Smads and Their Involvement in Cancer and Fibrosis
Susumu Itoh, Hiroyuki Suzuki, Fumiko Itoh, Kohei Miyazono, Mitsuyasu Kato
42. TGF-β-Related Antifibrotic Strategies in the Eye
M. Francesca Cordeiro, Annelie Maass, Clive Migdal, Li Guo
43. Transforming Growth Factor-β in Cutaneous Tissue Repair
Jisun Cha, Vincent Falanga
44. Topical Application of TGF-β1 Peptide Inhibitors for the Therapy of Skin Fibrosis
Javier Dotor, José L. Pablos
45. Overexpressed Truncated TGF-β Type II Receptor Inhibits Fibrotic Behavior of Keloid Fibroblasts In Vitro and Experimental Scar Formation In Vivo
Wei Liu, Chekhau Chua, Zhen Gao, Xiaoli Wu, Yilin Cao
Avainsanat: Medicine & Public Health, Oncology, Cell Biology, Cancer Research, Pharmacology/Toxicology
- Tekijä(t)
- Jakowlew, Sonia B.
- Julkaisija
- Springer
- Julkaisuvuosi
- 2008
- Kieli
- en
- Painos
- 1
- Sarja
- Cancer Drug Discovery and Development
- Sivumäärä
- 759 sivua
- Kategoria
- Terveys, kauneus, muoti
- Tiedostomuoto
- E-kirja
- eISBN (PDF)
- 9781597452922