Apoptosis, Senescence, and Cancer

I.Apoptosis and Alternative Modes of Cell Death

1. The Intrinsic Pathway of Apoptosis
Scott H. Kaufmann

2. The Extrinsic Pathway of Apoptosis
M. Stacey Ricci, Wafik S. El-Deiry

3. Evaluating the Importance of Apoptosis and OtherDeterminants of Cell Death and Survival
Bradly G. Wouters, Roland K. Chiu

4. Mitotic Catastrophe
Fiorenza Ianzini, Michael A. Mackey

5. Autophagy and Autophagic Cell Death
Mojgan Djavaheri-Mergny, Joëlle Botti, Patrice Codogno

6. Regulation and Function of Detachment-Induced Cell Death (Anoikis) in Cancer Progression and Metastasis
David J. McConkey, Victor Bondar

II.Telomeres and Telomerase, Senescence, Genomic Instability, and Tumorigenesis

7. Structure and Function of the Telomere
Jay E. Johnson, Dominique Broccoli

8. Overview of Senescence
Ruben D. Ramirez

9. Contributions of Telomerase to Tumorigenesis
Richard Possemato, William C. Hahn

10. The Role of Telomeres in Genomic Instability
John P. Murnane

III.DNA Damage Response, Signaling Pathways, and Tumorigenesis

11. Overview of the DNA Damage Checkpoint
Aude Duprè, Jean Gautier

12. Interactions Between Myc- and Cyclin-DependentKinase Inhibitors in Cancer
Kirsteen H. Maclean, John L. Cleveland

13. Interplay Between ?H2AX and 53BP1 Pathways inDNA Double-Strand Break Repair Response
Fatouros Chronis, Emmy P. Rogakou

14. DNA-Dependent Protein Kinase in Repair, Apoptosis, Telomere Maintenance, and Chemotherapy
Lawrence F. Povirk

IV.Resistance and Sensitization

15. Resistance/Signaling Pathways
Paul Dent, David T. Curiel, Paul B. Fisher

16. Ceramide and Multidrug Resistance
Myles C. Cabot

17. Chemo- and Radiosensitization Through Inhibition of PI3K/Akt Signaling
Debra L. Smith, Laura K. Nolden, Gordon B. Mills, Yiling Lu

18. The Advancement of Epidermal Growth Factor Receptor Inhibitors in Cancer Therapy
Gregory W. Allen, Paul M. Harari

V.Established Cancer Therapies

19. Antimetabolites
Janet A. Houghton

20. Topoisomerase I Poisons and Apoptotic Topoisomerase I-DNA Complexes
Olivier Sordet, Yves Pommier, Eric Solary

21. Perturbations of Cellular Functions by Topoisomerase II Inhibitors
Annette K. Larsen, DVM PhD, Andrzej Skladanowski, PhD DSc

22. The Significance of Poly-Targeting in Apoptosis Induction by Alkylating Agents and Platinum Drugs
Jan M. Woynarowski, Barbara A. Woynarowska

23. Contributions of Apoptosis and Senescence to Cytotoxicity Produced by Microtubule-Stabilizing Agents
Laura E. Klein, Susan Band Horwitz

24. Tyrosine Kinase Inhibitors
Michael Deininger

VI.Recent and Developing Cancer Therapies

25. Monoclonal Antibodies in Lymphomas
Richard R. Furman, John P. Leonard, Julian Decter, Morton Coleman

26. Role of Apoptosis in Anti-Angiogenic Cancer Therapies
Jennifer A. Doll PhD, Jennifer E. Hobbs PhD, Gerald A. Soff MD

27. Photodynamic Therapy-Induced Apoptosis
Nancy L. Oleinick, Rachel L. Morris, Anna-Liisa Nieminen

28. Modulation of TRAIL Signaling for Cancer Therapy
Simone Fulda, Klaus-Michael Debatin

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Avainsanat: MEDICAL / Public Health MED078000