Assessing Rare Variation in Complex Traits

1. Calling Rare Variants from Genotype Data
Jacqueline I. Goldstein, Benjamin M. Neale

2. Calling Variants from Sequence Data
Andy Rimmer

3. Rare Variant Quality Control
Anubha Mahajan, Neil Robertson

4. Rare Structural Variants
Menachem Fromer, Shaun Purcell

5. Functional Annotation of Rare Genetic Variants
Graham R. S. Ritchie, Paul Flicek

6. The 1000 Genomes Project
Adam Auton, Tovah Salcedo

7. The UK10K Project: 10,000 UK Genome Sequences—Accessing the Role of Rare Genetic Variants in Health and Disease
Dawn Muddyman

8. Population Isolates
Ilenia Zara

9. Natural Selection at Rare Variants
Yali Xue, Chris Tyler-Smith

10. Collapsing Approaches for the Association Analysis of Rare Variants
Jennifer L. Asimit, Andrew Morris

11. Rare Variant Association Analysis: Beyond Collapsing Approaches
Han Chen, Josée Dupuis

12. Significance Thresholds for Rare Variant Signals
Celia M. T. Greenwood, ChangJiang Xu, Antonio Ciampi

13. Power of Rare Variant Aggregate Tests
Manuel A. Rivas, Loukas Moutsianas

14. Replicating Sequencing-Based Association Studies of Rare Variants
Dajiang J. Liu, Suzanne M. Leal

15. Meta-Analysis of Rare Variants
Ioanna Tachmazidou, Eleftheria Zeggini

16. Population Stratification of Rare Variants
Emmanuelle Génin, Sébastien Letort, Marie-Claude Babron

17. Use of Appropriate Controls in Rare-Variant Studies
Audrey E. Hendricks

18. Trans-Ethnic Fine-Mapping of Rare Causal Variants
Xu Wang, Yik-Ying Teo

19. Erratum to: Functional Annotation of Rare Genetic Variants
Graham R. S. Ritchie, Paul Flicek

Avainsanat: Biomedicine, Human Genetics, Molecular Medicine, Statistics for Life Sciences, Medicine, Health Sciences