Hypoxia

Part I. Epigenetic Alterations in Hypoxia

1. Epigenetic Mechanisms as an Interface Between the Environment and Genome
Zdenko Herceg

2. Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans
Claudio Sartori, Stefano F. Rimoldi, Hervé Duplain, Thomas Stuber, Sophie Garcin, Emrush Rexhaj, Yves Allemann, Urs Scherrer

3. Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications
Stephen L. Archer

4. Epigenetics in Cardiovascular Regulation
Claudio Sartori, Stefano F. Rimoldi, Emrush Rexhaj, Yves Allemann, Urs Scherrer

Part II. Hypoxia and High Altitude Residents

5. Why Are High-Altitude Natives So Strong at Altitude? Maximal Oxygen Transport to the Muscle Cell in Altitude Natives
Carsten Lundby, Jose A. L. Calbet

6. Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness
Stefano F. Rimoldi, Emrush Rexhaj, Mercedes Villena, Carlos Salinas Salmon, Yves Allemann, Urs Scherrer, Claudio Sartori

7. Why Are High Altitude Natives So Strong at High Altitude? Nature vs. Nurture: Genetic Factors vs. Growth and Development
Tom Brutsaert

8. Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation
Jay F. Storz, Zachary A. Cheviron

Part III. Hypoxia and the Brain

9. Influence of Hypoxia on Cerebral Blood Flow Regulation in Humans
Craig D. Steinback, Marc J. Poulin

10. Imaging the Respiratory Effects of Opioids in the Human Brain
Kyle T. S. Pattinson, Richard G. Wise

11. Regional Cerebrovascular Responses to Hypercapnia and Hypoxia
Douglas R. Corfield, Leanne C. McKay

12. Implications of Oxygen Homeostasis for Tumor Biology and Treatment
Boyan K. Garvalov, Till Acker

13. Hyperoxia and Functional MRI
Daniel Bulte

14. Astrocytes and Brain Hypoxia
Nephtali Marina, Vitaliy Kasymov, Gareth L. Ackland, Sergey Kasparov, Alexander V. Gourine

15. Bidirectional Control of Blood Flow by Astrocytes: A Role for Tissue Oxygen and Other Metabolic Factors
Grant R. J. Gordon, Clare Howarth, Brian A. MacVicar

16. Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration
Rachel Speer, Rajiv R. Ratan

Part IV. Molecular Oxygen Sensing

17. Optical Analysis of Hypoxia Inducible Factor (HIF)-1 Complex Assembly: Imaging of Cellular Oxygen Sensing
Jun Hu, André Bernardini, Joachim Fandrey

18. Modulation of the Hypoxic Response
Christopher W. Pugh

Part V. Physiological Responses to Hypoxia

19. Central Sleep Apnea at High Altitude
Keith R. Burgess, Philip N. Ainslie

20. Multigenerational Effects of Rearing Atmospheric Oxygen Level on the Tracheal Dimensions and Diffusing Capacities of Pupal and Adult Drosophila melanogaster

C. Jaco Klok, Alexander Kaiser, John J. Socha, Wah-Keat Lee, Jon F. Harrison

21. Hypoxia and Its Acid–Base Consequences: From Mountains to Malignancy
Erik R. Swenson

22. Ensemble Input of Group III/IV Muscle Afferents to CNS: A Limiting Factor of Central Motor Drive During Endurance Exercise from Normoxia to Moderate Hypoxia
Markus Amann, Jerome A. Dempsey

23. Physiological and Clinical Implications of Adrenergic Pathways at High Altitude
Jean-Paul Richalet

24. Hemoglobin Mass and Aerobic Performance at Moderate Altitude in Elite Athletes
Jon Peter Wehrlin, Bernard Marti, Jostein Hallén

25. Does the Sympathetic Nervous System Adapt to Chronic Altitude Exposure?
Mikael Sander

26. Integrative Conductance of Oxygen During Exercise at Altitude
José A. L. Calbet, Carsten Lundby, Robert Boushel

27. Modeling Variable Phanerozoic Oxygen Effects on Physiology and Evolution
Jeffrey B. Graham, Corey J. Jew, Nicholas C. Wegner

28. Caudwell Xtreme Everest: An Overview
Michael P. W. Grocott, D. Z. H. Levett, D. S. Martin, M. H. Wilson, A. Mackenney, S. Dhillon, H. E. Montgomery, M. G. Mythen, K. Mitchell

29. Energy Flux, Lactate Shuttling, Mitochondrial Dynamics, and Hypoxia
George A. Brooks

30. Everest Physiology Pre-2008
John B. West

Avainsanat: Biomedicine, Human Physiology, Immunology, Neurosciences, Pneumology/Respiratory System