Next Generation Sequencing Technologies in Medical Genetics

Part I. Advances in Next-Generation–Sequencing Technology

1. Sanger Sequencing Principles, History, and Landmarks
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

2. A Survey of Next-Generation–Sequencing Technologies
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

3. A Review of DNA Enrichment Technologies
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

Part II. Clinical Applications of Next-Generation–Sequencing

4. Application of Next-Generation–Sequencing to the Diagnosis of Genetic Disorders: A Brief Overview
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

5. Next-Generation–Sequencing-Based Noninvasive Prenatal Diagnosis
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

6. Diagnosis of Inherited Neuromuscular Disorders by Next-Generation–Sequencing
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

7. Application of Next-Generation–Sequencing in Hearing Loss Diagnosis
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

8. Exome Sequencing as a Discovery and Diagnostic Tool
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

9. Challenges of Next-Generation–Sequencing-Based Molecular Diagnostics
C. Alexander Valencia, M. Ali Pervaiz, Ammar Husami, Yaping Qian, Kejian Zhang

Avainsanat: Biomedicine, Human Genetics, Gene Function, Biomedicine general