Advances in Tumor Immunology and Immunotherapy

Part I. Immune Activation, Suppression and Manipulation of the Immune Antitumor Response

1. Myeloid-Derived Suppressor Cells in Cancer
Christos E. Kyriakopoulos, Alberto J. Montero, Claudia Marcela Diaz-Montero

2. The Role of B Cells in Shaping the Antitumor Immune Response
Yu Zhang, Taylor H. Schreiber, Joseph D. Rosenblatt

3. Heat-Shock Protein-Based Cancer Immunotherapy
Taylor H. Schreiber

4. Activation of NK Cell Responses and Immunotherapy of Cancer
George J. Weiner

5. Induction of Tumor Immunity by Targeted Inhibition of Nonsense-Mediated mRNA Decay
Eli Gilboa

6. Employing T Cell Homeostasis as an Antitumor Strategy
Shawn M. Jensen, Christopher C. Paustain, Bernard A. Fox

7. Adoptive Cell Therapy of Systemic Metastases Using erbB-2-Specific T Cells Redirected with a Chimeric Antibody-Based Receptor
Dinorah Friedmann-Morvinski, Tova Waks, Assaf Marcus, Zelig Eshhar

Part II. Evolving Clinical Immunotherapeutic Strategies

8. Immunotherapy in Renal Cell Carcinoma
Jennifer Cudris, Jaime R. Merchan

9. Adoptive T-Cell Transfer as a Clinical Antitumor Strategy for Hematologic Malignancies
Aaron P. Rapoport, Nadia Ijaz

10. Bifunctional Antibodies: Preclinical and Clinical Applications
Casey W. Shuptrine, Louis M. Weiner

11. Clinical Development of Antibody-Fusion Proteins for Cancer Therapy
Kory L. Alderson, Amy K. Erbe, Margaret Boyden, Paul M. Sondel

12. Immunologic Outcomes of Allogeneic Stem Cell Transplantation: Graft-Versus-Host and Graft-Versus-Leukemia Responses and Implications for Future Therapy
Lazaros J. Lekakis, Krishna V. Komanduri

13. The Immune System in Head and Neck Squamous Cell Carcinoma: Interactions and Therapeutic Opportunities
Paolo Serafini, Donald T. Weed

14. T Cell Co-regulatory Signals and Their Role in Cancer Therapy
Eitan R. Friedman, Lynn Feun, Pasquale Benedetto, Joseph D. Rosenblatt

15. Assessment of Immune Response in Biotherapy Trials and Clinical Endpoints
Theresa L. Whiteside

Avainsanat: Biomedicine, Cancer Research, Pharmacology/Toxicology